Chronic periodontitis
Conditions
Interventions
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Men or women aged = 18 years old; 2. Simultaneously diagnosed with rheumatoid arthritis (2010ACR/EULAR diagnostic criteria) and stage III/IV periodontitis (2018 new classification); 3. In the active phase of the disease, with a DAS28 score of = 3.2; 4. Within 3 months prior to the screening visit, the medication, dosage, or formula for RA treatment should remain largely unchanged; 5. There are at least 15 natural teeth remaining in the mouth, and at least 4 teeth meet the following criteria: clinical attachment level (CAL) = 6 mm or periodontal probing depth (PD) = 5 mm; 6. Previously without systematic periodontal treatment; 7. Informed consent of the subjects.
Exclusion criteria
Exclusion criteria: 1. Have one or more infectious diseases, such as AIDS, hepatitis, infectious mononucleosis; 2. Suffering from known kidney disease (creatinine clearance rate<60ml/min) or liver disease; 3. Have unbalanced diabetes; 4. There is a risk of endocarditis; 5. Subjects with permanent pacemakers; 6. Subjects receiving antithrombotic treatment; 7. For women: pregnant or planning to conceive, or breastfeeding; 8. Subjects with chronic diseases who require long-term or intermittent use of antibiotics, and patients who receive medication known to affect periodontal status are also excluded (amoxicillin, etc.); 9. Subjects who have used any systemic or local immunosuppression (including steroids) within the past 6 months; 10. At least one of the following situations occurs: acute oral infection, acute oral pain (including pulpitis), suspected oral mucosal lesions, severe oral inflammation unrelated to periodontal disease, or ongoing orthodontic treatment; 11. Individuals with contraindications to local dental anesthesia; 12. Subjects who have serious difficulties in understanding written and spoken French; 13. Other circumstances that may affect the conduct of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DAS28(CRP): 28-Joint Disease Activity Score (C reactive protein); | — |
Secondary
| Measure | Time frame |
|---|---|
| ACR20: American College of Rheumatology 20;HAQ-DI: Health Assessment Questionnaire Disability Index; | — |
Countries
China
Contacts
Public ContactXU MINGMING
Peking University School and Hospital of Stomatology
Outcome results
None listed