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A prospective and cohort study of nimotuzumab at different gradient doses combined with concurrent chemoradiotherapy in the treatment of stage II.B-III.C of locally advanced cervical cancer

A prospective and cohort study of nimotuzumab at different gradient doses combined with concurrent chemoradiotherapy in the treatment of stage II.B-III.C of locally advanced cervical cancer

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066975
Enrollment
Unknown
Registered
2022-12-22
Start date
2023-01-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical cancer

Interventions

Experiment 1:Chemoradiotherapy in combination with nimotuzumab 100 mg weekly
Experiment 2:Chemoradiotherapy in combination with nimotuzumab 200 mg weekly
Experiment 3:Chemoradiotherapy in combination with nimotuzumab 400 mg weekly

Sponsors

Chengdu Fifth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-75 years old 2. Pathological diagnosis of cervical squamous cell carcinoma or adenocarcinoma, adenosquamous carcinoma 3. FIGO 2018 Staging IIB~IIIC 4. Confirmed by two gynecologists with higher deputy senior titles as inoperable 5. Have sufficient liver, kidney and bone marrow function before the start of the study 6. Physical condition score ECOG0-1 points 7. Estimated survival time> 6 months

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating patients 2.Have had other malignancies within 5 years (except completely cured carcinoma in situ or basal cell or cutaneous squamous cell carcinoma) 3. Those who have participated in other drug clinical trials or medical device trials within 1 month before starting treatment 4. Those with a history of severe allergies or specific constitutions 5. The investigator judges that it is not suitable to participate in the study

Design outcomes

Primary

MeasureTime frame
Tumor size;

Countries

China

Contacts

Public ContactHelang

Chengdu Fifth People's Hospital

helang729@163.com13990894622

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026