Perioperative sleep disturbance
Conditions
Interventions
saline group:saline nasal spry
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 200 Years
Inclusion criteria
Inclusion criteria: (1) Age>=65 years (2) Planned laparoscopic elective tumor resection; (3) Informed and signed consent form; (4) ASA Grade I-III; (5) The patient was admitted at least 2 days prior to the operation, and the expected postoperative hospital stay was 4 days or more.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications of nasal administration such as skull base fracture and cerebrospinal fluid leakage; (2) dexmedetomidine allergy; (3) Patients with the following arrhythmias: severe sinus bradycardia (heart rate < 50 times/min), grade II or above atrioventricular block without pacemaker implantation, sick sinus syndrome; (4) Patients with sleep apnea syndrome or B-APNEIC scale score of 3 or above; (5) Long-term use of psychotropic drugs or alcohol dependence; (6) had taken prescription sleeping drugs within 2 weeks before participating in the study; (7) require or have received dexmedetomidine or clonidine in addition to participating in the study; (8) Unable to communicate due to coma, dementia or speech disorder; (9) Preoperative delirium, mental illness (schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, etc.); (10) Patients who intend to undergo surgery via nasal route; (11) Abnormal sleep habits: go to bed before 21:00 or fall asleep after 2am; (12) Patients had moderate to severe pain (VAS score of 4 or above) affecting sleep. (13) Severe liver function impairment: serum total bilirubin =34.2umol/L or Child-Pugh grade C; (14) Severe renal impairment: GFR=60 or receiving dialysis before surgery; (15) Postoperative transfer to ICU was planned
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOS on the night of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| perioperative QOS;perioperative GTS score;perioperative AFS score;perioperative BFW score;objective parameters;anxiety;cognitive function;quality of life;Pain;delirium;sedation;long term sleep;living condition; | — |
Countries
China
Contacts
Public ContactZhen Liu
Beijing Hospital
Outcome results
None listed