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Establishment and evaluation of a differential diagnosis model for the etiology of hypertension: a laboratory-original mass spectrometry hormone detection project combined with a machine learning algorithm

Establishment and evaluation of a differential diagnosis model for the etiology of hypertension: a laboratory-original mass spectrometry hormone detection project combined with a machine learning algorithm

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052699
Enrollment
Unknown
Registered
2021-11-03
Start date
2021-11-20
Completion date
Unknown
Last updated
2022-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

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Interventions

Gold Standard:1. Essential hypertension: patients with hypertension should be clearly diagnosed according to the inclusion criteria, and other causes of secondary hypertension should be excluded
2. Primary aldosteronism: positive test results for confirmation. .
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Sponsors

Zhongshan Hospital affiliated to Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. In the case of not taking antihypertensive drugs, meet one of the following three; (1) Patients with systolic blood pressure >= 140 mmHg and/or diastolic blood pressure >= 90 mmHg with repeated blood pressure measurements 3 times on different days; (2) Patients with 24-hour ambulatory blood pressure monitoring with an average daily blood pressure of >= 135/85 mmHg; (3) Patients with an average blood pressure of >= 135/85 mmHg for 5-7 consecutive days by self-measured blood pressure at home. 2. Patients taking antihypertensive drugs but previously diagnosed with hypertension; 3. Aged 18 to 80 years.

Exclusion criteria

Exclusion criteria: 1. Patients with malignant tumors; 2. Patients who are taking glucocorticoid/mineralocorticoid analogs or antagonists; 3. Patients who are taking ACEI, ARB, diuretics or drugs containing licorice; 4. Patients with pregnancy or mental/intellectual disorders.

Design outcomes

Primary

MeasureTime frame
area under receiver operating curve;

Secondary

MeasureTime frame
Sensitivity;specificity;accuracy;positive predictive value;negative predictive value;

Countries

China

Contacts

Public ContactWang Beili

Zhongshan Hospital Affiliated to Fudan University

wang.beili1@zs-hospital.sh.cn+86 13585958413

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026