Cognitive development of children
Conditions
Interventions
intervention group:continued folic acid supplementation in middle/late pregnancy (400µg/d)
Control group:Stop to supply folic acid supplementation in middle/late pregnancy
Sponsors
Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women within 12 weeks of gestational age; 2. Aged 18 to 40 years; 3. No neuropsychiatric disorders, adequate understanding and expression ability; 4. Lived in Huaibei city more than half a year recently, and planned to give birth in Maternal and Child Hospital of Huaibei city; 5. The participants were healthy single pregnant women.
Exclusion criteria
Exclusion criteria: 1. Those who did not take folic acid supplements in early pregnancy; 2. Pregnant women with diabetes, hypertension, thyroid dysfunction or other diseases before pregnancy; 3. Participants taking drugs known to affect folate metabolism; 4. Pregnant women with liver and kidney diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Folic acid levels in maternal and umbilical blood;birth weight, length, head circumference, chest circumference;Cognitive development of children;body length, body weight, body composition; | — |
Secondary
| Measure | Time frame |
|---|---|
| postpartum depression; | — |
Countries
China
Contacts
Public ContactWang Sufang
Anhui Medical University
Outcome results
None listed