acute kidney injury
Conditions
Interventions
Gold Standard:Diagnostic criteria of AKI is according to the standard of improving the Global Renal Prognosis Organization (KDIGO): Scr increases more than 26.5µmol/l within 48-72 hours after surgery
of 
metalloproteinases-2(TIMP-2),urinary 
insulinlike 
protein-7(IGFBP-7)
Sponsors
Affiliated Children's Hospital of Capital Institute of Pediatrics
Eligibility
Sex/Gender
All
Age
No minimum to 6 Years
Inclusion criteria
Inclusion criteria: 1) Hospitalized for congenital heart disease in Affiliated Children's Hospital of Capital Institute of Pediatrics; 2) Age from 2 months to 6 years; 2) CPB operation; 4) The legal guardian gives informed consent to this study and signs relevant documents.
Exclusion criteria
Exclusion criteria: 1) Combined with renal abnormalities before surgery; 2) Combined with congenital urinary system malformation, such as polycystic kidney, single kidney, renal dysplasia, horseshoe kidney, etc.; 3) High-dose nephrotoxic drugs, including methotrexate, vancomycin, non-steroidal anti-inflammatory drugs, cyclosporin A and omeprazole, were used within 1 month or during this study; 4) Combined with other serious diseases ; 5) Combined with acute or chronic infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scr;urinary TIMP-2;urinary IGFBP-7;SEN, SPE, ACC, AUC of ROC; | — |
Countries
china
Contacts
Public ContactYanran Wang
Affiliated Children's Hospital of Capital Institute of Pediatrics
Outcome results
None listed