The effects on circRNAs’ expression in the plasma exosomes of patients with Perioperative Neurocognitive Disorders after noncardiac surgery
Conditions
Interventions
control group:After induction of anesthesia, 0.9%NS was injected under load, and then 0.9%NS was continuously pumped into the suture.
trial group:After anesthesia induction, 0.25 mg/kg S-ketamine was injected under load, and 0.125 mg/kg/h S-ketamine was continuously pumped until the suture.
Sponsors
Guiyang Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. 60 patients scheduled for non cardiac surgery; 2. Patients older than 18 years; 3. Patients weighing 40-120kg; 5. ASA: I-III patients.
Exclusion criteria
Exclusion criteria: 1. The patient refused; 2. Patients with existing neurological or mental disorders; 3. Patients with chronic pain syndrome; 4. Patients with any acute or chronic pain treated with opioids; 5. Patients with alcohol or drug abuse; 6. Patients with rheumatoid arthritis; 7. Patients with knee joint revision surgery; 8. Patients with severe liver and kidney dysfunction; 9. Patients with severe coronary artery disease; 10. Pregnant, alcohol or opioid addicts; 11. Patients with communication difficulties and poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;SpO2;BIS;NRS scores;TNF-a;IL-6;S100-ß;NSE;GFAP;WAIS-WMS-IV;hyperpathia;Plasma exosomes;circRNAs; | — |
Countries
China
Contacts
Public ContactYing Cao
Guiyang Second People's Hospital
Outcome results
None listed