Hypertonic saline for fluid?therapy in acute respiratory distress syndrome: study protocol for a preliminary randomized controlled clinical trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037612

Enrollment

Unknown

Registered

2020-08-29

Start date

2021-01-01

Completion date

Unknown

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory distress syndrome

Interventions

experimental group:3.0% hypertonic saline

control group:0.9% normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients will be eligible for study inclusion if they are aged at least 18 years old and meet the diagnostic criteria of ARDS as Berlin 2012, and judged by physicians that need fluids to maintain blood volume.

Exclusion criteria

Exclusion criteria: Patients will be excluded for any of the following reasons or conditions: no informed consent, known pregnancy or breastfeeding, not expected to live greater than 48 hours, post cardiac surgery, or combined with hypernatremia.

Design outcomes

Primary

Measure	Time frame
accumulated fluid volume during ICU stay;	—

Secondary

Measure	Time frame
cumulative urinary output;cumulative vasopressor dose;incidence of AKI;ventilator-free day;length of ICU stay;length of hospital stay;hospital mortality;ICU mortality;28-day all-cause mortality;	—

Countries

China

Contacts

Public ContactXuan Song

Liaocheng Cardiac Hospital

songxuan0303@163.com+86 17806359196

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026