Multi-center clinical study of refractory syphilis for standardized diagnosis and treatment

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037071

Enrollment

Unknown

Registered

2020-08-26

Start date

2020-11-01

Completion date

Unknown

Last updated

2020-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Syphilis

Interventions

Penicillin treatment group:Treat with Penicillin

Doxycycline treatment group:Treat with Doxycycline

Ceftriaxone treatment group:Treat with Ceftriaxone

Eligibility

Sex/Gender

All

Age

No minimum to 70 Years

Inclusion criteria

Inclusion criteria: 1. The cerebrospinal fluid (CSF) of patients with syphilis in each stage was consistent with the diagnosis of neurosyphilis; 2. Patients who voluntarily participated in the study.

Exclusion criteria

Exclusion criteria: 1. Patients with penicillin allergy; 2. Patients with severe heart, liver and kidney dysfunction; 3. Patients who do not want to have cerebrospinal fluid examination; 4. Syphilis patients during pregnancy and lactation.

Design outcomes

Primary

Measure	Time frame
Clinical symptoms;Laboratory indicators (peripheral blood RPR, cerebrospinal fluid VDRL, WBC, total protein, CXCL13 and Treponema pallidum load in cerebrospinal fluid, Treponema pallidum load in saliva);	—

Countries

China

Contacts

Public ContactPingyu Zhou

Shanghai Skin Disease Hospital

zhoupingyu@medmail.com.cn+86 18017336631

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026