Acute Kidney Injury
Conditions
Interventions
Gold Standard:Clinical outcomes
Index test:Alpha 
7-nicotinic 
acetylcholine 
(alpha 
7-nAChR), 
cell 
([TIMP-2]*[IGFBP7]), 
lipocalin 
(NGAL)
Sponsors
Beijing Institute of respiratory diseases / Beijing Chaoyang Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Consecutive high-risk AKI patients admitted to ICU immediately after surgery from July 2020 to June 2022 will be included. 1. Aged >= 18 years old; 2. Patients who meet at least one of the following high risk factors for AKI recommended by KDIGO guidelines: sepsis, critical illness (requiring vasoactive drugs or mechanical ventilation), severe trauma, non cardiac surgery, circulatory shock (systolic blood pressure < 90mmHg or 40mmhg lower than baseline value); 3. Patients with informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with ICU stay less than 72 hours; 2. Patients with chronic kidney disease; 3. Patients who received renal replacement therapy before operation; 4. Patients who received immunosuppressive therapy before or after operation; 5. Patients who are expected to die within 72 hours after operation due to massive hemorrhage and other reasons; 6. Patients with incomplete blood and urine samples were collected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of new AKI within 72 hours after admission to ICU;Early (within 7 days of AKI) renal function recovery in new onset AKI patients;mortality of 30 days in newly AKI patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| the duration of stay in ICU;the duration of stay in hospital; | — |
Countries
China
Contacts
Public ContactLi Wenxiong
Beijing Institute of respiratory diseases / Beijing Chaoyang Hospital Affiliated to Capital Medical University
Outcome results
None listed