early-onset schizophrenia
Conditions
Interventions
Gold Standard:Diagnositc criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM5).
measurements(total 
score 
and 
of 
Negetive 
Scale), 
psychosocial 
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
7 Years to 16 Years
Inclusion criteria
Inclusion criteria: The patient group: 1. Patients and their families/guardian agree to participate in this study and signed informed consent; 2. coming from the Han nationality; 3. aged between 7 and 16 years; 4. in the first episode and drug-naive, or with a washout period of at least 1 month; 5. meeting the diagnositc criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM5); 6. being diagnosed by two attending psychiatrists or senior psychiatrists independently with consistent diagonosis; 7. with a total score of the Positive and negative symptoms scale (PANSS)>= 60. The control group: 1. agreeing to participate in this study and signed informed consent; 2. coming from the Han nationality; 3. aged between 7 and 16 years; 4. meeting none of the diagnositc criterion in DSM5; 5. having no family history of psychiatric disorders or inherited neurologic diseases; 6. matches with the patient group according to age, sex and education.
Exclusion criteria
Exclusion criteria: The patient group: 1. Having a history of head injury and major body disease or other neural and psychiatric disorders; 2. having received modified electric convulsive therapy(MECT), antipsychotic treatment or antidepressant treatment in a month; 3. with a history of drug-induced neuroleptic malignant syndrome or severe tardive dyskinesia; 4. with severe suicide attempt or serious agitation; 5. with obvious abnormal laboratory results (AST or ALT of upper limit of normal or 2 times; BUN of upper limit of normal or 1.5 times;Cr of upper limit of normal or 1.2 times); QTc duration extended(male QTc >= 450ms or female QTc >= 470ms); 6. cannot be prescribed medication or guardian; 7. pregnant or breasting-feeding women,or planning a pregnancy; 8. resistent to two antipsychotics with different mechanisms; 9. having contraindications for the drugs recommended; 10. having contraindications for magnetic resonance imaging (MRI)scanning (such as pregnant women, patients with cardiac pacemakers, patients with aneurysm clip after craniocerebral surgery , patients with ferromagnetic implants, patients with artficial metal valve after heart surger,with metal prosthesis, metal joint, insulin pump or never stimulator in the body,etc); 11. having participated in other clinical trials in recent 30 days. The control group: 1.Having a history of brain organic diseases or other major body disease, neural and psychiatric disorders; 2. having a history of head injury and loss of consciousness for more than 30 minutes; 3. having a history of alcohol or drug abuse; 4. with obvious abnormal laboratory results (with the value more than 1.5 times of the upper limit of reference value range); 5. pregnant or breasting-feeding women; 6. having contraindications for magnetic resonance imaging (MRI)scanning; 7. having participated in other clinical trials in recent 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA, mRNA, miRNA of peripheral blood;brain images from magnetic resonance imaging (MRI) scanning;measurements of clinical symptoms;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| measurements of cognitive functions;measuments of psychosocial informantion; | — |
Countries
China
Contacts
Public ContactXu Yong
The First Hospital of Shanxi Medical University
Outcome results
None listed