hip and knee joint disease
Conditions
Interventions
one dose of 20mg IV-dexamethasone after the general anesthesia was well performed by an analgesist
B:one bolus of 60 mg/kg IV-TXA prior to skin incision, 5 boluses of 1g IV-TXA 3, 6, 12, 18 and 24 hours later
C:one bolus of 60 mg/kg IV-TXA prior to skin incision, 5 boluses of 1g IV-TXA 3, 12 and 24 hours later
D:one bolus of 60 mg/kg IV-TXA prior to skin incision, one dose of 2g IV-TXA 3 hours later
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients, aged 18 years or older, who were scheduled to have primary unilateral THA/TKA for osteoarthritis (OA) or ANFH were considered eligible for included in the trial.
Exclusion criteria
Exclusion criteria: Patients with anemia (<120 g/L for female, <130 g/L for male), cardiovascular problems (history of myocardial infraction, angina, and atrial fibrillation), cerebrovascular conditions (history of previous stroke), thromboembolic disorders (history of deep-vein thrombosis (DVT) or pulmonary embolism (PE)), clotting disorders, known allergy to TXA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory index (CRP IL-6 IL-10) ;fibrinolysis index (D-Dimer, FDP) ;total blood loss;Hidden blood loss;Hb drop;immune indices (C3, C4, IgG, IgA, IgM, CD3, CD4, CD8);VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| transfusion;Range of motion;Length of hospital stay ;swelling ratio;readmission rate; | — |
Countries
China
Contacts
Public ContactFuxing Pei
West China Hospital, Sichuan University
Outcome results
None listed