A:one bolus of 20 mg/kg IV-TXA prior to skin incision, 5 boluses of 1g IV-TXA 3, 6, 12, 18 and 24 hours later

The clinical effect of multiple high-dose intravenous tranexamic acid in peri-operative period of total hip/knee arthroplasty under the management of enhanced recovery after surgery: a prospective, randomized, controlled study

The antifibrinolytic and anti-inflammatory effect and safety of a loading high-dose intravenous tranexamic acid followed by multiple doses in peri-operative period of total hip/knee arthroplasty: a prospective, randomized, controlled trial