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Comparison of intranasal spray using midazolam, ketamine and dexmedetomidine for preoperative sedation in pediatric anesthesia

Comparison of intranasal spray using midazolam, ketamine and dexmedetomidine for preoperative sedation in pediatric anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17013744
Enrollment
Unknown
Registered
2017-12-06
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preoperative sedation

Interventions

placebo group:Normal saline
Midazolam group:midazole 0.4mg/kg was given before operation
Ketamine group:ketamine 8mg/kg was given before operation
Dexmedetomidine group:Dexmedetomidine 3ug/kg was given before operation

Sponsors

Shanghai Ninth People's Hospital, School Of Medicine, Shanghai Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 3 Years

Inclusion criteria

Inclusion criteria: 1. ASA I-II; 2. Aged 1-3years; 3. Elective surgery for children under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Allergic to study drugs; 2. A history of cardiovascular disease, abnormal liver/kidney/coagulation/nervous system function; 3. Cardia arrhythmia; 4. History of respiratory tract infection 1 week preoperatively; 5. Mental abnormalities; 6. Any congenital malformation disease; 7. difficult mask ventilation or intubation.

Design outcomes

Primary

MeasureTime frame
sedation score;—

Secondary

MeasureTime frame
separation time;heart rate;oxygen saturation;respiratory frequency;—

Countries

China

Contacts

Public ContactHuang Huimin

Shanghai Ninth People's Hospital, School Of Medicine, Shanghai Jiaotong University

drhhmin@163.com+86 13601629774

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026