Evaluation of a New Pain Management Regime for Oocyte Pick-Up During Fertility Treatment

Conditions

Acute procedural pain associated with oocyte pick-up (oocyte retrieval) in women undergoing IVF/ART.

Brief summary

Overall intra-procedural pain intensity during OPU, VAS 0–100 mm recorded every 2 minutes from first puncture to completion; primary derived measure (mean/median or VAS-AUC over time) per SAP.

Detailed description

Patient satisfaction with pain management at ~24 h post-OPU using APS-POQ-R., Post-OPU VAS pain at T0 (arrival in recovery), 30 min, 1 h, and discharge., Rescue analgesic use at home within 24 h (type/amount)., Nausea/vomiting incidence: pre-OPU, immediate post-OPU, 30 min, 1 h, discharge, and at 24 h., Respiratory depression/other AEs during and immediately after OPU (SpO₂, RR, clinical observation)., Vaginal bleeding (usual/less/more than usual)., Recovery metrics: time to discharge, procedure duration, number of oocytes retrieved, operator experience level., Hormonal/fertility markers: E2/FSH/LH/progesterone and follicle count (2 days pre-OPU); HCG 2 weeks post-ET; clinical pregnancy at ~7 weeks.

Related papers

No related papers found yet.

Papers published before 2008-02-04 may not appear yet. Historical indexing is in progress.

Interventions

DRUGDAFALGAN FORTE 1 g filmomhulde tabletten

DRUGXANAX 0

DRUG5 mg Tabletten

DRUGMidazolam Viatris 5 mg/ml oplossing voor injectie

DRUGLinisol 2 % oplossing voor injectie

DRUGDzuveo 30 micrograms sublingual tablet

DRUGVoltaren Retard 75 mg tabletten met verlengde afgifte.

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Overall intra-procedural pain intensity during OPU, VAS 0–100 mm recorded every 2 minutes from first puncture to completion; primary derived measure (mean/median or VAS-AUC over time) per SAP.	—

Secondary

Measure	Time frame
Patient satisfaction with pain management at ~24 h post-OPU using APS-POQ-R., Post-OPU VAS pain at T0 (arrival in recovery), 30 min, 1 h, and discharge., Rescue analgesic use at home within 24 h (type/amount)., Nausea/vomiting incidence: pre-OPU, immediate post-OPU, 30 min, 1 h, discharge, and at 24 h., Respiratory depression/other AEs during and immediately after OPU (SpO₂, RR, clinical observation)., Vaginal bleeding (usual/less/more than usual)., Recovery metrics: time to discharge, procedure duration, number of oocytes retrieved, operator experience level., Hormonal/fertility markers: E2/FSH/LH/progesterone and follicle count (2 days pre-OPU); HCG 2 weeks post-ET; clinical pregnancy at ~7 weeks.	—

Measure

Time frame

Patient satisfaction with pain management at ~24 h post-OPU using APS-POQ-R., Post-OPU VAS pain at T0 (arrival in recovery), 30 min, 1 h, and discharge., Rescue analgesic use at home within 24 h (type/amount)., Nausea/vomiting incidence: pre-OPU, immediate post-OPU, 30 min, 1 h, discharge, and at 24 h., Respiratory depression/other AEs during and immediately after OPU (SpO₂, RR, clinical observation)., Vaginal bleeding (usual/less/more than usual)., Recovery metrics: time to discharge, procedure duration, number of oocytes retrieved, operator experience level., Hormonal/fertility markers: E2/FSH/LH/progesterone and follicle count (2 days pre-OPU); HCG 2 weeks post-ET; clinical pregnancy at ~7 weeks.

—

Countries

Belgium

Outcome results

None listed