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DRUG12 trials

Sponsors

Alexion Pharmaceuticals Inc., Genentech Inc., CHRU De Nancy, Universitair Ziekenhuis Gent, University Medical Center Hamburg-Eppendorf

Conditions

Acute procedural pain associated with oocyte pick-up (oocyte retrieval) in women undergoing IVF/ART.Behaviors that challengeChronic heart failureER+ESR1-mutatedEstrogen Receptor (ER)-PositiveHER2-NegativeHER2– Advanced or Metastatic Breast Cancer

Phase 1

Phase 2

Phase 3

A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared with the Physician’s Choice of Endocrine Therapy Plus Everolimus in Patients with Estrogen Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer
Active, not recruitingCTIS2023-506821-12-00
Genentech Inc.Estrogen Receptor (ER)-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer previously treated with a CDK4/6 inhibitor and endocrine therapy
Start: 2023-10-12Target: 59Updated: 2025-12-17
Danish trial of beta blocker treatment after myocardial infarction without reduced ejection fraction (DANBLOCK)
CompletedCTIS2024-515748-22-01
Frederiksberg HospitalMyocardinal infarction
Start: 2018-12-01End: 2025-04-01Target: 2760Updated: 2024-08-22
SPondyloArthritis: inducing drug-free Remission by early TNF-Alpha bloCkade Under guidance of Single cell RNA sequencing and epigenetic profiling (SPARTACUS).
Active, not recruitingCTIS2023-510085-27-00
Universitair Ziekenhuis GentPeripheral Spondyloarthritis
Start: 2020-08-21Target: 150Updated: 2025-06-10
SPondyloArthritis: inducing drug-free Remission by early TNF-Alpha bloCkade Under guidance of Single cell RNA sequencing and epigenetic profiling (SPARTACUS).
Active, not recruitingCTIS2023-510085-27-00
Universitair Ziekenhuis GentPeripheral Spondyloarthritis
Start: 2020-08-21Target: 150Updated: 2025-06-10
Allogeneic stem cell transplantation vs. conventional therapy as salvage therapy for relapsed / progressive patients with multiple myeloma after a first-line therapy
CompletedCTIS2024-510590-14-00
University Medical Center Hamburg-Eppendorfmultiple myeloma
Start: 2023-03-03End: 2025-01-30Target: 400Updated: 2025-02-05
A randomized phase 3, double-blind, placebo-controlled study of elacestrant plus everolimus versus elacestrant in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative, ESR1-mutated, advanced breast cancer progressing to endocrine therapy and CDK4/6 inhibitors - The ADELA study-
RecruitingCTIS2024-512926-27-00
Medica Scientia Innovation Research S.L., Medica Scientia Innovation Research S.L., Stemline Therapeutics Inc.advanced breast cancer progressing to endocrine therapy and CDK4/6 inhibitors., ESR1-mutated, patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative
Start: 2024-12-12Target: 214Updated: 2025-02-13
Evaluation of a New Pain Management Regime for Oocyte Pick-Up During Fertility Treatment
Not yet recruitingCTIS2025-523018-10-00
UZ BrusselAcute procedural pain associated with oocyte pick-up (oocyte retrieval) in women undergoing IVF/ART.
Target: 318Updated: 2026-01-22

Phase 4