Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomized clinical trial

Following heart surgery, patients experience poor postoperative pain control and a moderate/high opioid consumptions. This is correlated to adverese events and poor outcome.

The primary endpoint will be cumulated intravenous morphineequivalent consumption within 48 hours from surgery

Intraoperative need for inotropes and vasopressors, Pain intensity assessed by the Numeric Rating Scale (NRS) at rest and at cough., Pain intensity assessed by the Numeric Rating Scale (NRS) during physiotherapeutic testing, Time from arrival in CICU until patient extubating and mobilization., CICU Length of stay (time from arrival at CICU until booking of transfer to the ward), Days until bowel function (movement, Flatus, stool), Quality of Recovery 1516 at postoperative day 0, 1, 2, 3, 30 and 90., Quality of life assessed by the SF-3617 after 90 days., Chronic pain assessment at 30 and 90 days after surgery., Time to hospital discharge., 3 months mortality, Reported occurrence of postoperative arrythmias

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