IMPACT OF ANTI-TNF, VEDOLIZUMAB AND TOFACITINIB ON AORTIC STIFFNESS, CAROTID INTIMA-MEDIA THICKNESS AND CARDIOVASCULAR RISK OF PATIENTS WITH ULCERATIVE COLITIS

Status

Not yet recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-517314-15-00

Acronym

PI2020_843_0114

Enrollment

100

Registered

2024-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ulcerative colitis

Brief summary

Carotid intima media thickness (CIMT)

Detailed description

Aortic pulse wave velocity (aPWV) / arterial stiffness, Augmentation index (AIx), Framingham score, the 10-year atherosclerotic CV disease risk (ASCVD) indices (reflect of the cardiovascular risk) and the SCORE score, Ulcerative colitis activity score /Mayo Score, Lipids parameters (HDL, LDL, TC, TG), Arterial tension and systolic pressure index, Endothelial function / Coagulation parameters

Interventions

DRUGAMGEVITA 40 mg solution for injection in pre-filled syringe

DRUGXELJANZ 5 mg film-coated tablets

DRUGEntyvio 300 mg powder for concentrate for solution for infusion

DRUGInflectra 100 mg powder for concentrate for solution for infusion

DRUGSimponi 45 mg/0.45 mL solution for injection in pre-filled pen.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Carotid intima media thickness (CIMT)	—

Secondary

Measure	Time frame
Aortic pulse wave velocity (aPWV) / arterial stiffness, Augmentation index (AIx), Framingham score, the 10-year atherosclerotic CV disease risk (ASCVD) indices (reflect of the cardiovascular risk) and the SCORE score, Ulcerative colitis activity score /Mayo Score, Lipids parameters (HDL, LDL, TC, TG), Arterial tension and systolic pressure index, Endothelial function / Coagulation parameters	—

Countries

France

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026