Inflectra 100 mg powder for concentrate for solution for infusion
Sponsors
AstraZeneca AB, UZ Leuven, Astrazeneca AB, Region Skane, Centre Hospitalier Universitaire Amiens Picardie
Conditions
Acute severe ulcerative colitisAdvanced Biliary Tract CancersAdvanced Hepatocellular CarcinomaAdvanced Non-Small Cell Lung CancerAdvanced hepatocellular carcinoma (HCC)Advanced or Metastatic Non-Small Cell Lung CancerCrohn´s diseaseEarly-stage (II to IIIB) Non-small Cell Lung Cancer
Phase 2
A Multicentre, Phase II, Single-Arm, Interventional Study of Neoadjuvant Durvalumab and Platinum-Based Chemotherapy (CT), followed by either Surgery and Adjuvant Durvalumab or Chemoradiotherapy (CRT) and consolidation Durvalumab, in participants with Resectable or Borderline Resectable Stage IIB-IIIB Non-Small Cell Lung Cancer (NSCLC)
Active, not recruitingCTIS2023-503357-35-00
Start: 2024-03-20Target: 124Updated: 2025-09-26
A Randomised, Open-Label, Phase 2 Study of Ceralasertib Monotherapy and Ceralasertib plus Durvalumab in Patients with Unresectable or Advanced Melanoma and Primary or Secondary Resistance to PD-(L)1 Inhibition
Active, not recruitingCTIS2024-512378-91-00
Start: 2022-06-24Target: 205Updated: 2025-06-16
A Biomarker-Directed Phase 2 Platform Study in Patients with Advanced Non-Small Cell Lung Cancer whose Disease has Progressed on First-Line Osimertinib Therapy (ORCHARD)
Active, not recruitingCTIS2023-504624-25-00
Start: 2019-09-26Target: 45Updated: 2025-02-26
A Phase II, Open-label, Multicentre, Randomised Study of Neoadjuvant and Adjuvant Treatment in Patients with Resectable, Early-stage (II to IIIB) Non-small Cell Lung Cancer (NeoCOAST-2)
RecruitingCTIS2023-508852-21-00
Start: 2022-06-10Target: 493Updated: 2025-08-01
Phase 3
A Phase IIIb Single Arm, Open-label, Multicentre Study of Durvalumab and Tremelimumab as First Line Treatment in Participants with Advanced Hepatocellular Carcinoma (SIERRA)
Active, not recruitingCTIS2022-502012-37-00
Start: 2023-10-06Target: 89Updated: 2025-10-14
A Phase IIIb, Single Arm, Open-label, Multicentre Study of Durvalumab in Combination with Chemotherapy for the First Line Treatment for Patients with Advanced Biliary Tract Cancers (TOURMALINE)
WithdrawnCTIS2022-502043-35-00
Target: 76Updated: 2023-09-04
A Phase III, Open-label, Randomised, Multicentre Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations, and Whose Disease Has Progressed On or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy: LATIFY
Active, not recruitingCTIS2023-509429-37-00
Start: 2022-10-03Target: 520Updated: 2025-08-29
A Phase IIIb, Single Arm, Open-label, Multicentre Study of Durvalumab in Combination with Chemotherapy for the First Line Treatment for Patients with Advanced Biliary Tract Cancers (TOURMALINE)
Active, not recruitingCTIS2022-502043-35-01
Start: 2024-04-24Target: 76Updated: 2025-11-26
A Phase III, Randomized, Double-Blind, Placebo Controlled, Multi-Center, International Study of Durvalumab Given Concurrently With Definitive Chemoradiation Therapy in Patients With Locally Advanced, Unresectable Esophageal Squamous Cell Carcinoma (KUNLUN).
Active, not recruitingCTIS2023-506413-22-00
Start: 2021-03-31Target: 48Updated: 2026-01-09
A Randomized, Open-label, Multi-center Phase III Study of Durvalumab and Tremelimumab as First-line Treatment in Patients with advanced Hepatocellular Carcinoma (HIMALAYA)
Active, not recruitingCTIS2024-512212-21-00
Start: 2017-11-28Target: 302Updated: 2025-12-16
IMPACT OF ANTI-TNF, VEDOLIZUMAB AND TOFACITINIB ON AORTIC STIFFNESS, CAROTID INTIMA-MEDIA
THICKNESS AND CARDIOVASCULAR RISK OF PATIENTS WITH ULCERATIVE COLITIS
Not yet recruitingCTIS2024-517314-15-00
Target: 100Updated: 2024-09-10
Phase 4
Stopping anti-TNF treatment in Crohn's and Colitis patients in remission
RecruitingCTIS2024-513299-17-00
Start: 2017-05-05Target: 350Updated: 2024-09-09
Model-informed precision dosing during infliximab rescue therapy for patients with steroid-refractory acute severe ulcerative colitis: an exploratory study
Not yet recruitingCTIS2023-503509-12-00
Target: 13Updated: 2024-12-18