DANOHCA: The Danish Out-of-Hospital Cardiac Arrest study

Patients resuscitated from out-of-hospital cardiac arrest

The protective effect of dexamethasone decided by all-cause mortality at 90 days following cardiac arrest, The protective effect of elevated backrest (30-45 degrees) decided by all-cause mortality at 90 days following cardiac arrest, The protective effect of early wake up and extubation ≤6 hours after admission decided by days alive outside hospital within 30 days, The protective effect of olanzapine decided by days alive outside hospital within 30 days

All-cause mortality at 90 days (in study strata where it is not a primary endpoint), Serum Neuron Specific Enolase and Light Chain Neurofilament levels at 48h, Markers of organ damage other than CNS: 1) TNT or TNI and CKMB (cardiac) and proBNP during initial 72h and 2) Creatinine during initial 72h and the use of dialysis during the first 30 days post OHCA (renal), Need for vasopressor during ICU stay. (cumulative doses during the first 36 hours and total doses), Mixed blood venous saturation after 12, 24 and 36 hours and the daily during ICU stay, Duration of intubation (oral and tracheostomy combined), Number of unconscious patients at 96 hours, Number of CAM-ICU positive patients 24 hours after extubation, Number of CAM-ICU negative days, Number of days without pharmacological treatment for delirium (other than study drug during the intervention period), ICU length of stay, Hospital length of stay (including in-patient rehabilitation and transfer to referral hospital), CPC and mRS at ICU discharge, at hospital discharge and at 90 days

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