Postoperative pain after a total knee arthroplasty
Conditions
Brief summary
Total morphine consumption within 24h after the surgery.
Detailed description
Pressure Pain Threshold, Punctate Pain Intensity, Allodynia zone, Pain intensity, Self reported safety outcomes, Measures of safety outcomes, Plasmatic and cerebrospinal fluid concentration of nefopam, Plasmatic and cerebrospinal fluid concentration of nefopam-beta-D-glucuronide, Plasmatic and cerebrospinal fluid concentration of nefopam-N-oxyde, Plasmatic and cerebrospinal fluid concentration of nefopam-N-demethyl, Plasmatic and cerebrospinal fluid concentration of Nefopam hydrochloride, Persistent postoperative pain - DN4 (or DN2 by phone), Persistent postoperative pain - DN4
Interventions
DRUGMORPHINE (CHLORHYDRATE) LAVOISIER 20 mg/ml
DRUGsolution injectable
DRUGSchweppes™
DRUGMORPHINE (SULFATE) LAVOISIER 50 mg/ml
DRUGMORPHINE (CHLORHYDRATE) AGUETTANT 0
DRUG1 mg/mL
Sponsors
Hospices Civils De Lyon
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total morphine consumption within 24h after the surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pressure Pain Threshold, Punctate Pain Intensity, Allodynia zone, Pain intensity, Self reported safety outcomes, Measures of safety outcomes, Plasmatic and cerebrospinal fluid concentration of nefopam, Plasmatic and cerebrospinal fluid concentration of nefopam-beta-D-glucuronide, Plasmatic and cerebrospinal fluid concentration of nefopam-N-oxyde, Plasmatic and cerebrospinal fluid concentration of nefopam-N-demethyl, Plasmatic and cerebrospinal fluid concentration of Nefopam hydrochloride, Persistent postoperative pain - DN4 (or DN2 by phone), Persistent postoperative pain - DN4 | — |
Countries
France
Outcome results
None listed