Patients with newly diagnosed primary central nervous system lymphoma naïve to surgery, radiotherapy or chemotherapy
Conditions
Brief summary
Standardized measurement of tumor uptake of [18F]-Fludarabine (Standard uptake value or SUV) in tumor lesions, relative to SUV of healthy tissue quantified on PET images superimposed on MRI.
Detailed description
Cerebral distribution and activity-time curves for [18F]-Fludarabine, Tumor/healthy tissue contrast on PET-[18F]-Fludarabine, Tumor SUVmax, tumor/healthy tissue ratio in PET- [18F]-FDG, lesion volumes in 3D T1 MRI with Gadolinium, Apparent diffusion coefficient (ADC) in diffusion MRI, Tumor perfusion in perfusion MRI, Metabolite ratios in spectroscopy, histological or cytological diagnosis
Interventions
DRUGGADOTERIC ACID
DRUG[18F]fludarabine
Sponsors
Assistance Publique Hopitaux De Paris
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized measurement of tumor uptake of [18F]-Fludarabine (Standard uptake value or SUV) in tumor lesions, relative to SUV of healthy tissue quantified on PET images superimposed on MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral distribution and activity-time curves for [18F]-Fludarabine, Tumor/healthy tissue contrast on PET-[18F]-Fludarabine, Tumor SUVmax, tumor/healthy tissue ratio in PET- [18F]-FDG, lesion volumes in 3D T1 MRI with Gadolinium, Apparent diffusion coefficient (ADC) in diffusion MRI, Tumor perfusion in perfusion MRI, Metabolite ratios in spectroscopy, histological or cytological diagnosis | — |
Countries
France
Outcome results
None listed