Add-on buprenorphine at analgesic doses for the treatment of severe suicidal ideas during a major depressive episode

Conditions

mental disorders

Brief summary

Scores on the Scale for Suicidal Ideation (SSI) at Day 7 for the last 7 days

Detailed description

Score on the SSI from D7 to 42 for the last 7 days (except at D2 = for the last 2 days), Psychological pain evaluation by a Visual Analog Scale (PPP-VAS) from D0 to D42 (current and for the last 7 days, except at D2 = for the last 2 days), Scores at the Beck Depression Inventory (BDI-II) and Montgomery-Asberg Depression Rating Scale (MADRS) after excluding the suicidal ideation items, for the last 7 days., Reports of the reasons for discontinuing treatment, Reports of suicide attempts and suicide completion after the treatment phase, Reports of side effects, Reports of withdrawal symptoms, Scores at neuropsychological tests, 3T Magnetic Resonance Imaging measurements, Blood and stool samples collection to create a biobank

Related papers

No related papers found yet.

Interventions

DRUGlactose monohydrate

DRUGBUPRENORPHINE

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Scores on the Scale for Suicidal Ideation (SSI) at Day 7 for the last 7 days	—

Secondary

Measure	Time frame
Score on the SSI from D7 to 42 for the last 7 days (except at D2 = for the last 2 days), Psychological pain evaluation by a Visual Analog Scale (PPP-VAS) from D0 to D42 (current and for the last 7 days, except at D2 = for the last 2 days), Scores at the Beck Depression Inventory (BDI-II) and Montgomery-Asberg Depression Rating Scale (MADRS) after excluding the suicidal ideation items, for the last 7 days., Reports of the reasons for discontinuing treatment, Reports of suicide attempts and suicide completion after the treatment phase, Reports of side effects, Reports of withdrawal symptoms, Scores at neuropsychological tests, 3T Magnetic Resonance Imaging measurements, Blood and stool samples collection to create a biobank	—

Measure

Time frame

Score on the SSI from D7 to 42 for the last 7 days (except at D2 = for the last 2 days), Psychological pain evaluation by a Visual Analog Scale (PPP-VAS) from D0 to D42 (current and for the last 7 days, except at D2 = for the last 2 days), Scores at the Beck Depression Inventory (BDI-II) and Montgomery-Asberg Depression Rating Scale (MADRS) after excluding the suicidal ideation items, for the last 7 days., Reports of the reasons for discontinuing treatment, Reports of suicide attempts and suicide completion after the treatment phase, Reports of side effects, Reports of withdrawal symptoms, Scores at neuropsychological tests, 3T Magnetic Resonance Imaging measurements, Blood and stool samples collection to create a biobank

—

Countries

France

Outcome results

None listed