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A Phase 2b Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects with Idiopathic Pulmonary Fibrosis

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-509784-24-00
Acronym
HZNP-HZN-825-303
Enrollment
17
Registered
2024-05-22
Start date
2022-05-11
Completion date
2024-10-30
Last updated
2024-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Pulmonary Fibrosis

Brief summary

Core Phase: Change in FVC % predicted from Baseline to Week 52. Extension Phase: Change from both Baselines in FVC % predicted at Week 104.

Detailed description

Core Phase: 1. Proportion of subjects with decline in FVC % predicted ≥10% from Baseline at Week 52. 2. Change from Baseline in the 6MWT results to Week 52. 3. Change from Baseline in K-BILD scores to Week 52. 4. Change from Baseline in L-IPF scores to Week 52. 5. Change from Baseline in LCQ scores to Week 52. Please refer to protocol section 8.1.2 and 8.2.2 for details

Interventions

DRUGmicrocrystalline cellulose
DRUGmagnesium stearate

Sponsors

Horizon Therapeutics Ireland Designated Activity Company
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Core Phase: Change in FVC % predicted from Baseline to Week 52. Extension Phase: Change from both Baselines in FVC % predicted at Week 104.

Secondary

MeasureTime frame
Core Phase: 1. Proportion of subjects with decline in FVC % predicted ≥10% from Baseline at Week 52. 2. Change from Baseline in the 6MWT results to Week 52. 3. Change from Baseline in K-BILD scores to Week 52. 4. Change from Baseline in L-IPF scores to Week 52. 5. Change from Baseline in LCQ scores to Week 52. Please refer to protocol section 8.1.2 and 8.2.2 for details

Countries

France, Greece, Italy, Netherlands, Poland, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026