polyvinyl alcohol

DRUG4 trials

Sponsors

Horizon Therapeutics Ireland Designated Activity Company, AstraZeneca AB, University of Washington

Conditions

Chronic Heart FailureDiffuse Cutaneous Systemic SclerosisIdiopathic Pulmonary FibrosisMalignant Neoplasm in the Head and NeckMetastatic Malignant Neoplasm in the Head and Neck

Phase 1

Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes

WithdrawnNCT05490381

University of WashingtonMalignant Neoplasm in the Head and Neck, Metastatic Malignant Neoplasm in the Head and Neck

Start: 2023-12-21End: 2025-01-31Updated: 2023-12-12

Phase 2

A Phase 2b Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects with Idiopathic Pulmonary Fibrosis

CompletedCTIS2023-509784-24-00

Horizon Therapeutics Ireland Designated Activity CompanyIdiopathic Pulmonary Fibrosis

Start: 2022-05-11End: 2024-10-30Target: 17Updated: 2024-12-18

A Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis [HZNP-HZN-825-301]

CompletedCTIS2023-509782-20-00

Horizon Therapeutics Ireland Designated Activity CompanyDiffuse Cutaneous Systemic Sclerosis

Start: 2021-11-11End: 2024-12-19Target: 84Updated: 2025-02-25

A Phase IIb Two-cohort, Randomised, Placebo-controlled, Double-blind, Multi-centre, Dose-ranging Study of AZD5462 in Stable Patients with Chronic Heart Failure

CompletedCTIS2023-510148-19-00

AstraZeneca ABChronic Heart Failure

Start: 2024-07-03End: 2026-01-21Target: 235Updated: 2025-12-01