Influence of Dexmedetomidine on the Human Glymphatic Cerebrospinal Fluid Flow, Neural Activity and Cerebral Blood Flow in Functional Magnetic Resonance Imaging (GlymphDex)

Conditions

Neurodegenerative disease; Delirium; Acute neurological disease

Brief summary

The primary outcome is the change in functional magnetic resonance signals or power spectra reflecting neural activity, brain pulsation, cerebral blood flow, and CSF flow with changing states of consciousness.

Detailed description

• Change in any MRI signal with drug concentrations, different states of consciousness, sedation-related EEG changes, and blood biomarkers., • Influence of physiological parameters on MRI signals, biomarkers, and EEG., • Comparison of regional and tissue specific differences in MRI between different states of consciousness and with different levels of sedation., • Correlation between MRI data, EEG data and peripheral blood biomarkers with sleep quality on the previous night., • Correlation of dexmedetomdine sedation with levels of biomarkers, particularly plasma sodium, plasma osmolality, blood glucose, serum insulin, plasma copeptin and serum cortisol levels., • Creating a model for glymphatic CSF flow in functional MRI (i.e. typical functional MRI signal/spectra).

Related papers

No related papers found yet.

Interventions

DRUGDexdor 100 micrograms/ml concentrate for solution for infusion

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
The primary outcome is the change in functional magnetic resonance signals or power spectra reflecting neural activity, brain pulsation, cerebral blood flow, and CSF flow with changing states of consciousness.	—

Secondary

Measure	Time frame
• Change in any MRI signal with drug concentrations, different states of consciousness, sedation-related EEG changes, and blood biomarkers., • Influence of physiological parameters on MRI signals, biomarkers, and EEG., • Comparison of regional and tissue specific differences in MRI between different states of consciousness and with different levels of sedation., • Correlation between MRI data, EEG data and peripheral blood biomarkers with sleep quality on the previous night., • Correlation of dexmedetomdine sedation with levels of biomarkers, particularly plasma sodium, plasma osmolality, blood glucose, serum insulin, plasma copeptin and serum cortisol levels., • Creating a model for glymphatic CSF flow in functional MRI (i.e. typical functional MRI signal/spectra).	—

Measure

Time frame

• Change in any MRI signal with drug concentrations, different states of consciousness, sedation-related EEG changes, and blood biomarkers., • Influence of physiological parameters on MRI signals, biomarkers, and EEG., • Comparison of regional and tissue specific differences in MRI between different states of consciousness and with different levels of sedation., • Correlation between MRI data, EEG data and peripheral blood biomarkers with sleep quality on the previous night., • Correlation of dexmedetomdine sedation with levels of biomarkers, particularly plasma sodium, plasma osmolality, blood glucose, serum insulin, plasma copeptin and serum cortisol levels., • Creating a model for glymphatic CSF flow in functional MRI (i.e. typical functional MRI signal/spectra).

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Countries

Finland

Outcome results

None listed