Primary aldosteronism
Conditions
Brief summary
Higher SUVmax between both adrenal glands on [68Ga]Ga-PTF-PET imaging, Ratio between SUVmax of both adrenal glands on [68Ga]Ga-PTF-PET imaging calculated as higher SUVmax / lower SUVmax of each adrenal gland, Difference between SUVmax of both adrenal glands on [68Ga]Ga-PTF-PET imaging calculated as the difference higher SUVmax - lower SUVmax of each adrenal gland, Ratio between the higher SUVmax among both adrenal glands and mean SUV of the liver on [68Ga]Ga-PTF-PET imaging
Detailed description
Aldosterone-to-cortisol ratio between the two adrenal veins on AVS (objective 1), Lateralization index during AVS (objective 1),, Ratio between the highest SUVmax among both adrenal glands and mean SUV of the liver on [68Ga]Ga-PTF-PET imaging (objective 2),, Secretion of aldosterone assessed with blood test after surgical adrenalectomy, dichotomized into persistence of PA at 6 months yes/no (objective 3),, CXCR4 expression levels by immuno-histochemistry (immunoreactive score or percentage of positive cells) (objective 4),, Adenoma sizes on CT and histology (objective 5), Safety and tolerance of [68Ga]Ga-PentixaFor injections (objective 6), Serious adverse events (any cause)., CYP11B2 expression levels by immuno- histochemistry (immunoreactive score or percentage of positive cells) (objective 7), Somatic mutation status of hypersecreting adrenal glands and APA (objective 8).
Interventions
Sponsors
Assistance Publique Hopitaux De Paris, Assistance Publique Hopitaux De Paris
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Higher SUVmax between both adrenal glands on [68Ga]Ga-PTF-PET imaging, Ratio between SUVmax of both adrenal glands on [68Ga]Ga-PTF-PET imaging calculated as higher SUVmax / lower SUVmax of each adrenal gland, Difference between SUVmax of both adrenal glands on [68Ga]Ga-PTF-PET imaging calculated as the difference higher SUVmax - lower SUVmax of each adrenal gland, Ratio between the higher SUVmax among both adrenal glands and mean SUV of the liver on [68Ga]Ga-PTF-PET imaging | — |
Secondary
| Measure | Time frame |
|---|---|
| Aldosterone-to-cortisol ratio between the two adrenal veins on AVS (objective 1), Lateralization index during AVS (objective 1),, Ratio between the highest SUVmax among both adrenal glands and mean SUV of the liver on [68Ga]Ga-PTF-PET imaging (objective 2),, Secretion of aldosterone assessed with blood test after surgical adrenalectomy, dichotomized into persistence of PA at 6 months yes/no (objective 3),, CXCR4 expression levels by immuno-histochemistry (immunoreactive score or percentage of positive cells) (objective 4),, Adenoma sizes on CT and histology (objective 5), Safety and tolerance of [68Ga]Ga-PentixaFor injections (objective 6), Serious adverse events (any cause)., CYP11B2 expression levels by immuno- histochemistry (immunoreactive score or percentage of positive cells) (objective 7), Somatic mutation status of hypersecreting adrenal glands and APA (objective 8). | — |
Countries
France
Outcome results
None listed