[68Ga]Ga-PentixaFor
Sponsors
Centre Hospitalier Universitaire De Nantes, Pentixapharm AG, University Of Antwerp, Assistance Publique Hopitaux De Paris, Assistance Publique Hopitaux De Paris, Stichting Radboud universitair medisch centrum
Conditions
Cardiac SarcoidosisCentral nervous system (CNS) lymphoma; recurrent or refractory primary or isolated secondaryCushing s SyndromeHyperaldosteronismHypercortisolismMarginal Zone LymphomaMultiple MyelomaMultiple myeloma
Early Phase 1
Phase 1
[68Ga]Ga-PentixaFor positron emission tomography for improved risk and disease assessment in myeloma
RecruitingCTIS2022-501811-14-00
Start: 2024-09-20Target: 90Updated: 2025-10-09
An open-label dose escalation study to evaluate safety, tolerability, biodistribution and efficacy of [90Y]Y-PentixaTher for the therapy of recurrent or refractory primary or isolated secondary central nervous system lymphoma
RecruitingCTIS2024-512097-98-00
Start: 2023-11-07Target: 15Updated: 2026-01-27
CHEMOKINE RECEPTOR CXCR4-DIRECTED THERANOSTICS OF ADVANCED LYMPHOPROLIFERATIVE CANCERS BY RADIOPEPTIDE-BASED IMAGING AND THERAPY:
THE COLPRIT PHASE I/II STUDY
Not yet recruitingCTIS2024-517639-35-00
Target: 38Updated: 2024-10-14
ProspectivE phase 0 pilot study, assessing potential prognostic and theranostic interest of 68Ga-PentiXafor PET-CT In metastatic triple neGative brEast caNCer patiEnts (EXIGENCE)
RecruitingCTIS2024-517658-90-00
Start: 2025-12-01Target: 12Updated: 2025-03-24
Phase 2
Relevance of [68Ga]Ga -PentixaFor-PET for Initial Staging and Therapeutic Evaluation of Multiple Myeloma
RecruitingNCT04561492
Start: 2021-09-21End: 2030-05-21Target: 45Updated: 2025-12-08
Relevance Evaluation of [68Ga]Ga-PentixaFor for Initial Staging and Detection of Minimal Residual Disease in Multiple Myeloma Patients.
WithdrawnNCT05321862
Start: 2023-03-14End: 2023-05-04Updated: 2023-11-15
Exploratory study evaluating the relevance of [68Ga]Ga-PentixaFor for initial staging and detection of minimal residual disease in multiple myeloma patients eligible for autologous stem cell transplantation less than 66 years included in the prospective IFM 2020-02.
CompletedCTIS2022-500339-35-01
End: 2023-05-23Target: 45Updated: 2023-03-13
Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism
RecruitingNCT06246357
Start: 2024-09-23End: 2028-04-01Target: 80Updated: 2025-12-09
PENTALON - Pilot study for the evaluation of [68Ga]Ga-PentixaFor PET imaging for the identification of unilateral adrenal secretion of ALdosterON in patients with primary aldosteronism.
RecruitingCTIS2023-505507-22-00
Start: 2024-09-12Target: 60Updated: 2025-03-04
CXCR4-directed [68Ga]Ga-PentixaFor PET/CT vs AVS performance in a diagnoStic randomized Trial Ultimately comparing hypertenSion outcome in primary aldosteronism (CASTUS trial)
RecruitingCTIS2024-512628-12-00
Start: 2025-01-28Target: 228Updated: 2025-10-08
Exploratory study evaluating the relevance of [68Ga]Ga-PentixaFor for initial staging and therapeutic evaluation of symptomatic multiple myeloma patients in first line treatment or in relapse.
RecruitingCTIS2024-516752-18-00
Start: 2021-09-21Target: 60Updated: 2024-09-20
Accuracy for Imaging Cardiac Sarcoidosis with 68Ga-Pentixafor Positron Emission Tomography/Computed Tomography (68Ga-Pentixafor PET/CT): ASPECT study
Not yet recruitingCTIS2025-523646-27-00
Target: 20Updated: 2026-02-12
Phase 3
[68Ga]Ga-PentixaFor-PET Imaging for Staging of Marginal Zone Lymphoma
TerminatedNCT06125028
Start: 2024-05-20End: 2025-07-18Updated: 2025-09-05
A pivotal phase 3 clinical trial to assess the diagnostic performance and safety of [68Ga]Ga-PentixaFor ([68Ga]Ga-PTF), a positron emission tomography (PET) imaging agent, versus [18F]FDG PET/CT imaging, for staging of patients with confirmed marginal zone lymphoma (MZL) exemplary for CXCR4-positive malignant lymphomas: a prospective, international, multi-center, comparative, randomized, cross-over, open-label lymphoma diagnostic trial (LYMFOR).
CompletedCTIS2022-500918-25-00
Start: 2024-05-20End: 2025-06-06Target: 148Updated: 2025-07-01