Healthy volunteers
Conditions
Brief summary
• Number of naloxone administrations
Detailed description
• Number of naloxone administrations, • Timing of minute ventilation, end-tidal PCO2 and plasma concentrations of naloxone, • Plasma concentrations of naloxone and fentanyl, • Pupil diameter and muscle tone
Interventions
DRUGZIMHI™ (naloxone hydrochloride injection) for intramuscular or subcutaneous use
DRUGNARCAN® (naloxone hydrochloride) nasal spray
DRUGoplossing voor injectie
Sponsors
Leiden University Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Number of naloxone administrations | — |
Secondary
| Measure | Time frame |
|---|---|
| • Number of naloxone administrations, • Timing of minute ventilation, end-tidal PCO2 and plasma concentrations of naloxone, • Plasma concentrations of naloxone and fentanyl, • Pupil diameter and muscle tone | — |
Countries
Netherlands
Outcome results
None listed