Naloxone 400 micrograms/ml solution for injection/infusion

DRUG3 trials

Sponsors

Leiden University Medical Center, Academisch Ziekenhuis Leiden

Conditions

Healthy volunteershealthy subjectshealthy subjects onlynone

Phase 2

Comparison of multiple doses of intramuscular versus intranasal naloxone for reversal of opioid toxicity

CompletedCTIS2023-505338-93-00

Leiden University Medical CenterHealthy volunteers

Start: 2023-09-21End: 2024-09-06Target: 22Updated: 2023-08-14

Phase 3

L-NAC for reversal of opioid-induced respiratory depression

CompletedCTIS2023-503912-34-00

Leiden University Medical Centerhealthy subjects only, none

Start: 2023-07-19End: 2024-09-09Target: 18Updated: 2024-04-22

Fentanyl effect on ventilatory pattern under sham postsurgical conditions – an exploratory study in healthy men and women – the FAME study

CompletedCTIS2023-508915-22-00

Academisch Ziekenhuis Leidenhealthy subjects, none

Start: 2024-03-04End: 2024-04-26Target: 12Updated: 2024-01-15

Related Papers

A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial

Nature Communications2025-05-196 citations