Comparison of STep-up and step-down therapeutic strategies in childhood ARthritiS

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2023-505051-43-00

Acronym

The STARS trial

Enrollment

260

Registered

2024-09-04

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

juvenile idiopathic arthritis

Brief summary

Clinical remission on or off medication at 12 months.

Detailed description

The rate of patients who achieve the JADAS/JIA ACR state of ID at any single point in time throughout the study period will be compared between the 2 arms.

Interventions

DRUGReumaflex 50 mg/ml soluzione iniettabile

DRUGsiringa preriempita

DRUGEnbrel 25 mg solution for injection in pre-filled syringe

DRUGEnbrel 10 mg powder and solvent for solution for injection for paediatric use

DRUGEnbrel 50 mg solution for injection in pre-filled syringe

Eligibility

Sex/Gender

All

Age

0 Years to 17 Years

Design outcomes

Primary

Measure	Time frame
Clinical remission on or off medication at 12 months.	—

Secondary

Measure	Time frame
The rate of patients who achieve the JADAS/JIA ACR state of ID at any single point in time throughout the study period will be compared between the 2 arms.	—

Countries

Italy

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026