stroke or transient ischemic attack
Conditions
Brief summary
the correlation between: - Plasma levels of ficolin-2 at day 5, - Metabolic data on [18F]DPA-714 PET/MRI: standardized uptake value (SUV) and Logan distribution volume ratio (DVR) of [18F]DPA-714 in carotids and brain at the time of the PET-Scan imaging (day 5).
Detailed description
• Plasma levels of ficolin-2 at day 5 when correlating with morphological data and at day-15 when correlating with histological data, • Morphological data evaluated by the Central Image Reading Board at day 5: - on carotid plaque PET/MRI: presence of intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap on carotid plaque MRI - on brain PET/MRI: infarct size, hemorrhagic transformation, and blood-brain barrier leakage evaluated by the Central Image Readin
Interventions
DRUGGADOTERIC ACID
DRUG18F-DPA-714
Sponsors
Hospices Civils De Lyon
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the correlation between: - Plasma levels of ficolin-2 at day 5, - Metabolic data on [18F]DPA-714 PET/MRI: standardized uptake value (SUV) and Logan distribution volume ratio (DVR) of [18F]DPA-714 in carotids and brain at the time of the PET-Scan imaging (day 5). | — |
Secondary
| Measure | Time frame |
|---|---|
| • Plasma levels of ficolin-2 at day 5 when correlating with morphological data and at day-15 when correlating with histological data, • Morphological data evaluated by the Central Image Reading Board at day 5: - on carotid plaque PET/MRI: presence of intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap on carotid plaque MRI - on brain PET/MRI: infarct size, hemorrhagic transformation, and blood-brain barrier leakage evaluated by the Central Image Readin | — |
Countries
France
Outcome results
None listed