depression, mental disorders
Conditions
Brief summary
Brain activity measured by fMRI in regions involved in effort assessment before and after treatment: basolateral amygdala, dorsal anterior cingulate cortex, ventral pallidum, ventral striatum, ventral tegmental area
Detailed description
Delta depression scores before & after treatment (Quick Inventory of Depressive Symptomatology, Clinician Rated and Self-report) at inclusion visit, 4 days, 1 month and 3 months., Delta of Behavioral Activation for Depression Scale (BADS) and Snaith-Hamilton Pleasure Scale (SHAPS) scores before and after treatment., Evaluation of therapy administration sessions by patients: satisfaction, number and severity of adverse events or tolerance problems reported., 5-Dimensional Altered States of Consciousness Questionnaire score.
Interventions
DRUGPSILOCYBINE
Sponsors
Centre Hospitalier Universitaire De Nimes
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain activity measured by fMRI in regions involved in effort assessment before and after treatment: basolateral amygdala, dorsal anterior cingulate cortex, ventral pallidum, ventral striatum, ventral tegmental area | — |
Secondary
| Measure | Time frame |
|---|---|
| Delta depression scores before & after treatment (Quick Inventory of Depressive Symptomatology, Clinician Rated and Self-report) at inclusion visit, 4 days, 1 month and 3 months., Delta of Behavioral Activation for Depression Scale (BADS) and Snaith-Hamilton Pleasure Scale (SHAPS) scores before and after treatment., Evaluation of therapy administration sessions by patients: satisfaction, number and severity of adverse events or tolerance problems reported., 5-Dimensional Altered States of Consciousness Questionnaire score. | — |
Countries
France
Outcome results
None listed