Efficacy of early intravenous high-dose vitamin C in post-cardiac arrest shock: a multicenter, randomized controled to standard treatment, open label trial.

Conditions

cardiac arrest

Brief summary

Cumulative incidence of weaning from vasopressors at day 3 after OHCA.

Detailed description

Cumulative incidence of death by refractory shock within 7 days after OHCA., the neurological outcome at day 28 after OHCA, assessed using the mRS (favorable neurological outcome will be considered if mRS range from 0 to 3; Unfavorable neurological outcome will be considered if mRS range from 4 to 6)., The maximal vasopressors infusion dose within 3 days after OHCA., The delta SOFA (sepsis-related organ failure assessment score) is defined as the difference between SOFA admission and SOFA at 72 hours after OHCA. Death within 72 hours will be counted as the maximum SOFA score (i.e. 24 points)., The lower arterial lactate level at day 3 after OHCA.

Jonathan Chelly, Noémie Peres, G. Sboui, Julien Maizel, Marion Beuzelin et al. (15 authors)

BMJ Open2024-09-011 citations

10.1136/bmjopen-2024-087303

Interventions

DRUGLAROSCORBINE 1 g/5 ml

DRUGsolution injectable I.V. en ampoule

DRUGADRENALINE AGUETTANT 1 mg/ml SANS SULFITE

DRUGsolution injectable

DRUGDOBUTAMINE PANPHARMA 250 mg/20 ml

DRUGsolution à diluer pour perfusion

DRUGBEVITINE 100 mg/2 ml

DRUGsolution injectable en ampoule

DRUGNORADRENALINE (TARTRATE) AGUETTANT 2 mg/ml (SANS SULFITES)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Secondary

Measure	Time frame
Cumulative incidence of death by refractory shock within 7 days after OHCA., the neurological outcome at day 28 after OHCA, assessed using the mRS (favorable neurological outcome will be considered if mRS range from 0 to 3; Unfavorable neurological outcome will be considered if mRS range from 4 to 6)., The maximal vasopressors infusion dose within 3 days after OHCA., The delta SOFA (sepsis-related organ failure assessment score) is defined as the difference between SOFA admission and SOFA at 72 hours after OHCA. Death within 72 hours will be counted as the maximum SOFA score (i.e. 24 points)., The lower arterial lactate level at day 3 after OHCA.	—

Measure

Time frame

Cumulative incidence of death by refractory shock within 7 days after OHCA., the neurological outcome at day 28 after OHCA, assessed using the mRS (favorable neurological outcome will be considered if mRS range from 0 to 3; Unfavorable neurological outcome will be considered if mRS range from 4 to 6)., The maximal vasopressors infusion dose within 3 days after OHCA., The delta SOFA (sepsis-related organ failure assessment score) is defined as the difference between SOFA admission and SOFA at 72 hours after OHCA. Death within 72 hours will be counted as the maximum SOFA score (i.e. 24 points)., The lower arterial lactate level at day 3 after OHCA.

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Primary

Measure	Time frame
Cumulative incidence of weaning from vasopressors at day 3 after OHCA.	—

Countries

France

Outcome results

None listed