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DRUG9 trials

Sponsors

Centre Hospitalier Bethune Beuvry, Centre Hospitalier Universitaire De Nantes, Assistance Publique Hopitaux De Paris, Centre Medico Chirurgical Ambroise Pare Hartmann, CHRU De Nancy

Conditions

Alzheimer DiseaseCardiorespiratory arrest at birth in full-term newbornsKnee arthroscopyOut-of-hospital cardiac arrest.Patients in ICU with invasive mechanical ventilation and HSV throat reactivation with 1 or no organ failures.Post-operative pain after surgerySickle cell diseasecardiac arrest

Phase 1

Safety and Efficacy of a Unilateral Subretinal Administration of HORA PDE6B in Patients with Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6ß Expression
CompletedCTIS2024-511687-90-00
eyeDNA Therapeuticsretinitis pigmentosa
Start: 2017-10-12End: 2025-06-30Target: 23Updated: 2024-05-17

Phase 2

Efficacy of early intravenous high-dose vitamin C in post-cardiac arrest shock: a multicenter, randomized controled to standard treatment, open label trial.
RecruitingCTIS2022-500717-64-00
Centre Hospitalier Bethune Beuvrycardiac arrest
Start: 2023-12-27Target: 234Updated: 2025-10-03
Therapeutic evaluation of low-dose IL-2-based immunomodulatory approach in patients with early AD
Not yet recruitingCTIS2024-516565-36-00
Groupe Hospitalier Universitaire Paris Psychiatrie Et NeuroscienceAlzheimer Disease
Target: 45Updated: 2025-06-13
Umbilical vein catheterization through Wharton’s jelly in the delivery room : CaDOm multicenter clinical trial.
RecruitingCTIS2024-515249-41-00
Hopital NOVOCardiorespiratory arrest at birth in full-term newborns
Start: 2025-10-01Target: 26Updated: 2025-06-11

Phase 3

Preemptive Treament with acyclovir in intubated and mechanically ventilated patients with Herpes simplex virus oropharyngeal reactivation and one or less organ failure (PTH2)
RecruitingCTIS2023-505510-26-00
Assistance Publique Hopitaux De ParisPatients in ICU with invasive mechanical ventilation and HSV throat reactivation with 1 or no organ failures.
Start: 2024-06-19Target: 246Updated: 2026-01-07
TOCIACS : Efficacy and safety of Tocilizumab for acute chest syndrome treatment in paediatric and adult patients with sickle cell disease
RecruitingCTIS2023-505109-17-00
Assistance Publique Hopitaux De ParisSickle cell disease
Start: 2025-08-27Target: 130Updated: 2025-12-17
Impact of low dose epinephrine in the management of out-of-hospital cardiac arrest on neurological outcome: A multicenter randomized and double-blind trial (Low-EPI Study)
Not yet recruitingCTIS2023-505349-26-00
CHRU De NancyOut-of-hospital cardiac arrest.
Target: 4336Updated: 2025-10-08
Efficacy of intravenous dexamethasone in prolonging the duration of spinal anesthesia with chloroprocaine in knee arthroscopy.
Not yet recruitingCTIS2023-505247-39-00
Centre Medico Chirurgical Ambroise Pare HartmannKnee arthroscopy
Target: 60Updated: 2026-04-08

Phase 4

Avoid With locoregional Analgesia Persistant Postoperative Pain After Surgery In Children
RecruitingCTIS2023-503499-25-00
Centre Hospitalier Universitaire De NantesPost-operative pain after surgery
Start: 2024-06-06Target: 222Updated: 2024-10-11

Related Papers

Early intravenous high-dose vitamin C in postcardiac arrest shock (VICEPAC): study protocol for a randomised, single-blind, open-label, multicentre, controlled trial
BMJ Open2024-09-011 citations