Yohimbine

DRUG17 trials

Sponsors

National Institute of Mental Health (NIMH), Vanderbilt University, Medical University of South Carolina, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Walter Ritter GmbH & Co

Conditions

AlcoholismAutonomic FailureAutonomic Nervous System DiseasesBorderline Personality DisorderCocaine Related DisordersEarly Life TraumaErectile DysfunctionHealthy

Early Phase 1

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

TerminatedNCT02963181

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sAutonomic Nervous System Diseases, Hypertension, Hypotension, Orthostatic

Start: 2018-03-01End: 2019-05-28Updated: 2019-06-12

Phase 1

Treatment of Orthostatic Hypotension in Autonomic Failure

CompletedNCT00223691

Vanderbilt UniversityAutonomic Failure, Orthostatic Hypotension

Start: 2002-03-31End: 2017-01-31Updated: 2017-01-18

Effects of Stress and Drug-cue Exposure (SCM)

CompletedNCT03154567

Wayne State UniversityMarijuana Abuse

Start: 2017-11-01End: 2023-10-27Updated: 2024-04-23

Phase 2

The Effect of Yohimbine on Cocaine Cue Reactivity

CompletedNCT00535002

Medical University of South CarolinaCocaine Related Disorders

Start: 2007-09-30End: 2012-08-31Updated: 2017-06-07

Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics

CompletedNCT00605904

National Institute on Alcohol Abuse and Alcoholism (NIAAA)Alcoholism

Start: 2008-01-31End: 2011-03-31Updated: 2012-07-03

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) With/Without Yohimbine

CompletedNCT01031979

VA Office of Research and DevelopmentPost-Traumatic Stress Disorder

Start: 2010-12-01End: 2015-07-07Updated: 2018-02-07

Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant

CompletedNCT01593215

Anders Rosengren, MD PhDType 2 Diabetes

Start: 2012-05-31End: 2014-10-31Updated: 2015-01-09

Phase 4

Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine

CompletedNCT00975325

Walter Ritter GmbH & CoErectile Dysfunction

Start: 2009-10-31End: 2010-12-31Updated: 2015-06-26

Role Of Sensitivity to neuroEndocrine Systems in Social Decisions

WithdrawnNCT06018727

University of North Carolina, Chapel HillBorderline Personality Disorder

Start: 2024-07-31End: 2025-07-31Updated: 2024-06-05

Unknown Phase

Brain Receptors in Sympathetic Nervous System Regulation

CompletedNCT00029627

National Institute of Mental Health (NIMH)Healthy

Start: 2002-01-31End: 2004-12-31Target: 200Updated: 2008-03-04

Effects of Stress Hormones on Emotion and Cognition

CompletedNCT00032838

National Institute of Mental Health (NIMH)Healthy

Start: 2002-03-31End: 2006-01-31Target: 170Updated: 2008-03-04

The Role of Sympatho-vagal Balance on Different Limbs of Pain Perception in Healthy Subjects

Tel-Aviv Sourasky Medical CenterPain

Start: 2012-08-31End: 2014-08-31Target: 20Updated: 2012-06-18

Noradrenergic Activity, Cognition and Major Depressive Disorder

CompletedNCT02470026

Charite University, Berlin, GermanyEarly Life Trauma, Major Depressive Disorder

Start: 2014-06-30End: 2018-10-31Updated: 2019-05-23

Influence of the Noradrenergic System on the Formation of Intrusive Memories

CompletedNCT02541071

Charite University, Berlin, GermanyIntrusive Memories

Start: 2013-11-30End: 2014-10-31Updated: 2015-09-04

The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat

CompletedNCT04359147

Charite University, Berlin, GermanyHydrocortisone, Placebo, Yohimbine +1

Start: 2019-11-01End: 2021-12-22Updated: 2022-03-15

Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions

CompletedNCT06939608

University Medicine GreifswaldPharmacokinetic Study in Healthy Volunteers

Start: 2025-04-28End: 2025-10-10Updated: 2026-01-21

Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans

Not yet recruitingNCT07817030

University Medicine GreifswaldPharmacokinetic Study in Healthy Volunteers

Start: 2026-09-21End: 2027-12-31Target: 30Updated: 2026-09-14

Related Papers

Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension

Hypertension2024-12-275 citations

Effects of stress-related neuromodulators on amygdala and hippocampus resting state functional connectivity

Journal of Psychopharmacology2024-06-202 citations

Predictors of the Pressor Response to the Norepinephrine Transporter Inhibitor, Atomoxetine, in Neurogenic Orthostatic Hypotension

Hypertension2021-06-2822 citations

Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension

Hypertension2016-06-0776 citations