whole brain radiotherapy

RADIATION13 trials

Sponsors

Merck Sharp & Dohme LLC, University Hospital, Essen, Assistance Publique - Hôpitaux de Paris, Betta Pharmaceuticals Co., Ltd., International Extranodal Lymphoma Study Group (IELSG)

Conditions

Brain MetastasasesBrain MetastasesBrain MetastasisBreast Cancer MetastaticCarcinoma, Non-Small-Cell LungDiffuse Large B-cell LymphomaEGFR-mutated Lung AdenocarcinomaLeptomeningeal Disease

Phase 1

Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation

CompletedNCT01516983

Betta Pharmaceuticals Co., Ltd.Brain Metastases, Non-small Cell Lung Cancer

Start: 2011-12-31End: 2013-12-31Updated: 2014-02-17

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

CompletedNCT03719768

H. Lee Moffitt Cancer Center and Research InstituteLeptomeningeal Disease, Leptomeningeal Metastases

Start: 2019-06-10End: 2024-08-21Updated: 2026-03-02

Phase 2

Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED)

TerminatedNCT00266812

Merck Sharp & Dohme LLCCarcinoma, Non-Small-Cell Lung

Start: 2005-03-08End: 2008-01-16Updated: 2017-06-08

Whole-Brain Radiotherapy (WBRT) Versus WBRT and Integrated Boost Using Helical Tomotherapy for Multiple Brain Metastases

University Hospital, EssenBrain Metastases

Start: 2009-04-30End: 2013-07-31Target: 160Updated: 2009-04-07

New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement

CompletedNCT02329080

International Extranodal Lymphoma Study Group (IELSG)Diffuse Large B-cell Lymphoma

Start: 2014-12-31End: 2024-03-22Updated: 2025-07-08

Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases.

Stephanie CombsBrain Metastasases

Start: 2016-04-30End: 2018-05-31Target: 60Updated: 2017-09-20

Phase 3

EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC

Sun Yat-sen UniversityNon-Small Cell Lung Cancer

Start: 2015-08-31End: 2022-12-31Target: 601Updated: 2017-10-27

FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma

RecruitingNCT07058428

Sun Yet-Sen University Cancer CenterMultiple Brain Metastases in Lung Adenocarcinoma

Start: 2025-06-30End: 2028-12-30Target: 258Updated: 2025-12-02

Unknown Phase

Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis

TerminatedNCT01363557

Assistance Publique - Hôpitaux de ParisBrain Metastasis, EGFR-mutated Lung Adenocarcinoma

Start: 2012-03-31End: 2013-05-31Updated: 2014-05-13

Whole Brain Radiotherapy (WBRT) Versus Stereotactic Radiosurgery (SRS) for 4 Upto 10 Brain Metastases

TerminatedNCT02353000

Maastricht Radiation OncologyNeoplasm Metastasis

Start: 2016-07-31End: 2019-12-31Updated: 2020-06-01

Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy

CompletedNCT02913534

Institut de Cancérologie de LorraineBrain Metastasis

Start: 2014-03-31End: 2014-06-30Updated: 2016-09-23

Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer

Affiliated Hospital to Academy of Military Medical SciencesBrain Metastases, Breast Cancer Metastatic

Start: 2015-08-31End: 2017-08-31Target: 120Updated: 2016-12-23

The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?

RecruitingNCT05378633

University Hospital HeidelbergBrain Metastases, Nsclc

Start: 2022-02-24End: 2028-02-24Target: 190Updated: 2026-03-10

Related Papers

Phase IB study of Avelumab and whole brain radiotherapy in patients with leptomeningeal disease from solid tumors: Results and molecular analyses

Neuro-Oncology2025-08-281 citations

CTSI-01 FINAL RESULTS AND MOLECULAR ANALYSES OF THE PHASE IB CLINICAL TRIAL OF AVELUMAB AND WHOLE BRAIN RADIOTHERAPY (WBRT) IN PATIENTS WITH LEPTOMENINGEAL DISEASE (LMD) FROM SOLID MALIGNANCIES.

Neuro-Oncology Advances2025-08-01

Phase 1B study of avelumab and whole brain radiotherapy (WBRT) in patients with leptomeningeal disease (LMD) from epithelial carcinomas: Final results and molecular analyses with single cell RNA sequencing.

Journal of Clinical Oncology2023-06-011 citations

Quality of life among patients with 4 to 10 brain metastases after treatment with whole-brain radiotherapy vs. stereotactic radiotherapy: a phase III, randomized, Dutch multicenter trial

Annals of Palliative Medicine2021-11-1916 citations

MATRix-RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial.

2021-02-0177 citations

A Dutch phase III randomized multicenter trial: whole brain radiotherapy versus stereotactic radiotherapy for 4–10 brain metastases

Neuro-Oncology Advances2021-01-0136 citations

Sequential Matrix-RICE Therapy Followed By Autologous Stem Cell Transplant in Patients with Diffuse Large B-Cell Lymphoma and Secondary Central Nervous System Involvement: The International Extranodal Lymphoma Study Group-42 Phase II (MARIETTA) Trial

Blood2019-11-132 citations

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation

Zurich Open Repository and Archive (University of Zurich)2019-09-02

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation.

2019-07-0161 citations

P05.31 Plan quality of stereotactic radiosurgery in a multicenter phase III randomized trial in patients with 4 up to 10 brain metastases

Neuro-Oncology2018-09-01

Whole brain radiotherapy versus stereotactic radiosurgery for 4-10 brain metastases: a phase III randomised multicentre trial.

2017-07-2539 citations

Phase I trial of icotinib combined with whole brain radiotherapy for EGFR-mutated non-small cell lung cancer patients with brain metastases.

Journal of Clinical Oncology2014-05-203 citations