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Very low nicotine content cigarettes

OTHER14 trials

Sponsors

Wake Forest University Health Sciences, Brown University, Saul Shiffman, University of Vermont, Duke University

Conditions

ADHDE-Cig UseNicotine DependenceNicotine Dependence, Cigarettes, UncomplicatedSmokingSmoking, CigaretteTobacco DependenceTobacco Smoking

Phase 1

Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
CompletedNCT02232737
Brown UniversityTobacco Use Disorder
Start: 2016-10-07End: 2019-01-14Updated: 2022-12-07
Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women
CompletedNCT02250534
University of VermontTobacco Use Disorder
Start: 2016-10-31End: 2019-10-31Updated: 2022-12-01
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
CompletedNCT02250664
University of VermontTobacco Use Disorder
Start: 2016-10-31End: 2019-10-31Updated: 2022-12-01
Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
CompletedNCT03860077
Brown UniversityNicotine Dependence, Cigarettes, Uncomplicated
Start: 2019-10-10End: 2022-03-23Updated: 2023-12-19
Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women
CompletedNCT04033237
University of VermontTobacco Use Disorder
Start: 2019-08-21End: 2024-08-19Updated: 2026-05-18

Phase 2

Very Low Nicotine Cigarettes in Smokers With Schizophrenia
CompletedNCT02019459
Brown UniversityTobacco Dependence
Start: 2014-11-17End: 2017-08-31Updated: 2018-04-09

Phase 3

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace
CompletedNCT03272685
University of MinnesotaNicotine Dependence, Tobacco Smoking
Start: 2018-06-01End: 2023-01-10Updated: 2024-08-20

Unknown Phase

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes
CompletedNCT01681875
Wake Forest University Health SciencesTobacco Dependence
Start: 2013-06-30End: 2014-07-31Updated: 2018-08-15
Very-Low Nicotine Cigarettes and Non-Daily Smokers
CompletedNCT02228824
Saul ShiffmanSmoking
Start: 2015-06-30End: 2017-07-31Updated: 2018-10-31
Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers
CompletedNCT02587312
Brown UniversityNicotine Dependence
Start: 2016-10-13End: 2019-08-31Updated: 2022-10-27
Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers
TerminatedNCT02599571
Duke UniversityADHD, Nicotine Dependence
Start: 2016-03-30End: 2019-09-12Updated: 2020-01-27
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
CompletedNCT02989038
Duke UniversityNicotine Dependence
Start: 2017-01-31End: 2019-12-17Updated: 2020-03-04
Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes
CompletedNCT03612960
Milton S. Hershey Medical CenterTobacco Dependence
Start: 2020-02-20End: 2023-06-23Updated: 2024-08-20
Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2
CompletedNCT05473585
Duke UniversityE-Cig Use, Nicotine Dependence, Smoking +1
Start: 2022-10-12End: 2023-05-09Updated: 2023-07-19

Related Papers

Titration of nicotine intake in smokers switching to reduced nicotine content cigarettes with access to alternative nicotine systems: Secondary analysis of a randomized clinical trial.
2026-03-19
Secondary analysis of a randomized clinical trial of very low nicotine cigarettes: Outcomes across social and demographic groups.
2025-07-21
Pilot randomized clinical trial examining use of very low nicotine content cigarettes during pregnancy in the United States.
2025-07-05
Reduced nicotine in cigarettes in a marketplace with alternative nicotine systems: randomized clinical trial.
2024-06-0318 citations
Potential effects of nicotine content in cigarettes on use of other substances.
2022-10-053 citations
Effects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide and Self-Reported Respiratory Health Outcomes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage
Nicotine & Tobacco Research2021-07-126 citations
Cumulative vulnerabilities as a potential moderator of response to reduced nicotine content cigarettes.
2021-07-078 citations
Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage
JAMA Network Open2020-10-2068 citations
Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations
Preventive Medicine2020-07-0312 citations
Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes
Tobacco Control2018-11-0112 citations
Nondaily Smokers’ Changes in Cigarette Consumption With Very Low-Nicotine-Content Cigarettes
JAMA Psychiatry2018-06-1446 citations
Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.
Experimental and Clinical Psychopharmacology2018-03-0512 citations
Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes
Tobacco Control2016-11-1718 citations
The Impact of Smoking Very Low Nicotine Content Cigarettes on Alcohol Use
Alcoholism Clinical and Experimental Research2016-02-2527 citations
Randomized Trial of Reduced-Nicotine Standards for Cigarettes
New England Journal of Medicine2015-09-30397 citations