Vaginal brachytherapy

RADIATION8 trials

Conditions

Adjuvant RadiotherapyCervical CancerEndometrial CancerEndometrial Cancer Stage IEndometrial Cancer Stage IIMolecular Classification

Phase 1

Whole-Abdominal Radiation Therapy and Cisplatin in Treating Patients With Stage III or Stage IV Endometrial Cancer That Has Been Removed by Surgery

CompletedNCT00448643

University of MiamiEndometrial Cancer

Start: 2002-05-31End: 2011-03-31Updated: 2016-12-15

Phase 2

Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features

RecruitingNCT05255653

Leiden University Medical CenterEndometrial Cancer

Start: 2021-11-11End: 2031-01-01Target: 1615Updated: 2026-05-15

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

RecruitingNCT05640999

Canadian Cancer Trials GroupEndometrial Cancer

Start: 2022-12-19End: 2029-06-30Target: 393Updated: 2026-09-15

Phase 3

External-Beam Radiation Therapy Compared With Vaginal Brachytherapy After Surgery for Stage I Endometrial Cancer

CompletedNCT00376844

Leiden UniversityEndometrial Cancer

Start: 2002-05-31End: 2016-04-30Updated: 2022-04-12

PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer

Active, not recruitingNCT03469674

Leiden University Medical CenterEndometrial Cancer Stage I, Endometrial Cancer Stage II

Start: 2016-06-10End: 2028-12-31Target: 550Updated: 2023-10-11

Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions

Not yet recruitingNCT05524389

Peking Union Medical College HospitalAdjuvant Radiotherapy, Endometrial Cancer, Molecular Classification

Start: 2022-12-01End: 2027-06-30Target: 624Updated: 2022-11-23

Unknown Phase

PROfiling Based Endometrial Cancer Adjuvant Therapy

RecruitingNCT05179447

Women's Hospital School Of Medicine Zhejiang UniversityEndometrial Cancer Stage I, Endometrial Cancer Stage II

Start: 2022-01-24End: 2027-01-01Target: 590Updated: 2025-04-01

Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study

RecruitingNCT05857631

Tata Memorial CentreCervical Cancer, Endometrial Cancer

Start: 2023-05-29End: 2029-05-25Target: 90Updated: 2025-04-15

2026-01-01

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors.

2025-02-111 citations

CCTG EN10: A phase II study of tailored adjuvant therapy in <i>POLE</i>-mutated and p53-wildtype/NSMP early-stage endometrial cancer (EC)—RAINBO BLUE and TAPER.

Journal of Clinical Oncology2023-06-015 citations

The RAINBO MMRd-GREEN trial (GCIG/DGOG/ENGOT-EN14<sup>2</sup>): A phase III trial on the addition of adjuvant durvalumab to radiotherapy in patients with high-risk MMRd endometrial cancer.

Journal of Clinical Oncology2023-06-014 citations

Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program.

2023-01-03129 citations

Molecular profile-based recommendations for postoperative adjuvant therapy in early endometrial cancer with high-intermediate or intermediate risk: a Chinese randomized phase III trial (PROBEAT)

Journal of Gynecologic Oncology2023-01-017 citations

Adjuvant Treatment Recommendations in Early-Stage Endometrial Cancer: What Changes With the Introduction of The Integrated Molecular-Based Risk Assessment.

2021-09-0113 citations

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.

2020-10-12173 citations

Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial.

2019-07-22303 citations