Transdermal estradiol

DRUG14 trials

Sponsors

National Institute of Mental Health (NIMH), University of Wisconsin, Madison, University of Washington, University of Medicine and Dentistry of New Jersey, OHSU Knight Cancer Institute

Conditions

AgingAlzheimer DiseaseAnhedoniaBleedingBlood PressureCancerContraceptionDepression

Early Phase 1

Investigation of Female Reproductive Hormone Dynamics During Adolescence

CompletedNCT02486757

Massachusetts General HospitalMenstruation Disturbances

Start: 2015-04-30End: 2016-03-01Updated: 2018-12-24

Phase 2

Alzheimer's Disease: Therapeutic Potential of Estrogen

CompletedNCT00066157

University of Wisconsin, MadisonAlzheimer Disease

Start: 2001-09-30End: 2007-12-31Updated: 2018-08-23

Neoadjuvant Estradiol or Androgen Deprivation in Clinically Localized Prostate Cancer

CompletedNCT00167648

University of WashingtonCancer, Prostate Neoplasms

Start: 2005-03-31End: 2006-12-31Updated: 2009-01-19

Phase II Trial of Transdermal Estradiol for Hormone Refractory Prostate Cancer

TerminatedNCT00176644

University of Medicine and Dentistry of New JerseyProstate Cancer

Start: 2005-05-31End: 2008-12-31Updated: 2023-09-13

Paclitaxel Poliglumex and Estradiol in Treating Patients With Stage IV Prostate Cancer

TerminatedNCT00459810

OHSU Knight Cancer InstituteProstate Cancer

Start: 2007-02-28End: 2009-07-31Updated: 2017-04-28

The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass

TerminatedNCT01928082

University of ChicagoHypercalciuria, Hypercalciuria, Familial Idiopathic, Osteopenia +1

Start: 2013-08-01End: 2014-08-01Updated: 2018-12-10

Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality

TerminatedNCT06191289

University of Illinois at ChicagoSuicide

Start: 2024-03-16End: 2024-12-01Updated: 2025-10-29

Phase 4

Raloxifene and Rimostil for Perimenopause-Related Depression

CompletedNCT00030147

National Institute of Mental Health (NIMH)Depression, Perimenopausal Depression

Start: 2002-02-28End: 2015-06-30Updated: 2016-09-05

Postpartum Depression: Transdermal Estradiol Versus Sertraline

TerminatedNCT00744328

Northwestern UniversityPostpartum Depression

Start: 2008-08-31End: 2013-09-30Updated: 2019-09-10

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

RecruitingNCT05282277

University of North Carolina, Chapel HillAnhedonia, Depression, Psychosis

Start: 2022-04-20End: 2026-12-31Target: 103Updated: 2025-02-26

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

RecruitingNCT06610305

University of North Carolina, Chapel HillMajor Depressive Disorder

Start: 2024-09-02End: 2028-06-01Target: 75Updated: 2025-10-29

Unknown Phase

A Randomized Controlled Trial of Oral Naproxen and Transdermal Estradiol for Bleeding in LNG-IUC

CompletedNCT00789802

Washington University School of MedicineBleeding, Contraception

Start: 2008-11-30End: 2011-01-31Updated: 2018-03-20

Hormone Replacement and Neural Cardiovascular Control in Postmenopausal Women

TerminatedNCT01633814

University of Missouri-ColumbiaAging, Blood Pressure, Menopause

Start: 2011-09-30End: 2015-08-31Updated: 2017-08-10

Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone Therapy

Not yet recruitingNCT07496294

Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalHormone Therapy, Menopausal Hormone Therapy, Menopausal Symptom Relief +1

Start: 2026-04-01End: 2027-10-01Target: 200Updated: 2026-03-27

Related Papers

Perimenopausal Effects of Estradiol on Anhedonia and Psychosis Study (PEEPs): study protocol for a neural and molecular mechanistic clinical trial.

2023-02-285 citations