Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)

DEVICE16 trials

Sponsors

Northwell Health, Medical University of South Carolina, Burrell College of Osteopathic Medicine, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, University of Wisconsin, Madison

Conditions

AgingAlcohol Use Disorder (AUD)Alzheimer DiseaseAppetite RegulationAuditory Processing Disorder, CentralAuditory Processing DisordersAutonomic DysfunctionAutonomic Imbalance

Phase 1

The ENHANCE Study: taVNS and Psilocybin

RecruitingNCT05866471

University of Wisconsin, MadisonHealthy, Psychedelic Experiences, Vagus Nerve Stimulation

Start: 2025-01-27End: 2028-01-01Target: 108Updated: 2026-04-03

Phase 2

Investigation to Understand and Optimize Psilocybin

RecruitingNCT06512194

Charles RaisonDepression

Start: 2025-05-13End: 2029-05-31Target: 141Updated: 2025-05-23

Unknown Phase

Non-Invasive Bioelectronic Analytics

Enrolling by invitationNCT04100486

Northwell HealthAutonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases +1

Start: 2019-08-29End: 2025-09-30Target: 48Updated: 2025-05-31

Noninvasive VNS to Facilitate Excitability in Motor Cortex

CompletedNCT04130646

Medical University of South CarolinaMotor Activity, Stroke, Stroke Sequelae

Start: 2020-03-15End: 2024-12-06Updated: 2025-04-20

Anti-inflammatory Actions of Osteopathic Manipulative Treatment

Burrell College of Osteopathic MedicineInflammation

Start: 2020-01-06End: 2023-08-31Target: 36Updated: 2023-02-08

TAES for FPVCs: a Pragmatic, Randomized Controlled Trial

RecruitingNCT04415203

Guang'anmen Hospital of China Academy of Chinese Medical SciencesPremature Ventricular Complexes

Start: 2020-06-04End: 2025-12-31Target: 90Updated: 2025-07-20

Effects of Transcutaneous Vagus Nerve Stimulation (taVNS) in Individuals With Primary Dysmenorrhea

CompletedNCT06146569

Artvin Coruh UniversityDysmenorrhea Primary, Pain

Start: 2023-11-15End: 2024-01-30Updated: 2024-10-29

Post-stroke Pain taVNS

CompletedNCT06456385

Medical University of South CarolinaPain, Stroke

Start: 2024-06-04End: 2024-09-26Updated: 2025-08-22

Safety and Feasibility of Paired Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury

RecruitingNCT06543277

The University of Texas Health Science Center, HoustonChronic Incomplete Cervical Spinal Cord Injury (SCI)

Start: 2025-08-15End: 2027-12-30Target: 12Updated: 2025-09-19

The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF

RecruitingNCT06742788

Xijing HospitalInfertility Assisted Reproductive Technology

Start: 2025-03-04End: 2025-12-30Target: 90Updated: 2025-07-02

taVNS Effect on Central Auditory Processing

CompletedNCT06970444

Medipol UniversityAuditory Processing Disorder, Central, Auditory Processing Disorders, Central Auditory Disease +1

Start: 2023-04-01End: 2024-07-19Updated: 2025-05-14

Research on the Heart-Brain Coupling Mechanisms and Interventions for Emotional Inhibitory Control Deficits in Individuals With Alcohol Use Disorder

CompletedNCT07036055

Shanghai Mental Health CenterAlcohol Use Disorder (AUD)

Start: 2024-03-15End: 2024-08-31Updated: 2025-06-25

Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia

RecruitingNCT07123987

Mohamed Hosny Ismail EasaPost Herpetic Neuralgia (PHN)

Start: 2025-09-07End: 2026-09-09Target: 34Updated: 2026-03-18

Vagus Nerve Stimulation to Enhance Memory in Aging

Not yet recruitingNCT07214194

Stanford UniversityAging, Alzheimer Disease

Start: 2027-02-28End: 2028-07-31Target: 150Updated: 2025-10-09

Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease

Not yet recruitingNCT07337226

Fondazione Policlinico Universitario Campus Bio-MedicoIdiopathic Parkinson's Disease (PD)

Start: 2026-01-31End: 2027-10-31Target: 60Updated: 2026-01-13

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Appetite

CompletedNCT07444177

Seoul National University HospitalAppetite Regulation, Eating Behaviour, Food Intake +1

Start: 2026-01-12End: 2026-02-12Updated: 2026-03-04

Related Papers

Transcutaneous Auricular Neurostimulation Modulates Pain Perception in Survivors of Stroke With Chronic Upper-Extremity Pain: A Randomized, Sham-Controlled Pilot Study.

2026-01-16

Effects of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals with Primary Dysmenorrhea: A Randomized Controlled Trial.

2025-10-17

Efficacy and safety of transcutaneous auricular vagus nerve stimulation for frequent premature ventricular complexes: rationale and design of the TASC-V trial.

2024-07-291 citations

Transcutaneous auricular vagus nerve stimulation may elicit anti-inflammatory actions through activation of the hypothalamic-pituitary-adrenal axis in humans

Physiology2023-05-011 citations

A method to quantify autonomic nervous system function in healthy, able-bodied individuals.

2021-08-2719 citations