Torsemide

DRUG13 trials

Conditions

Drug BiotransformationEdemaGenotype-related Drug MetabolismHealthyHeart FailureHeart Failure, CongestiveMembrane TransportPreeclampsia

Phase 1

Bioavailability Study of Torsemide Tablets Under Fasting Conditions

CompletedNCT00653549

Par Pharmaceutical, Inc.To Determine Bioequivalence Under Fasting Conditions

Start: 2001-04-30End: 2001-05-31Updated: 2011-06-17

Bioavailability Study of Torsemide Tablets Under Fed Conditions

CompletedNCT00654043

Par Pharmaceutical, Inc.Healthy

Start: 2001-04-30End: 2001-05-31Updated: 2008-04-11

A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)

TerminatedNCT01558674

Merck Sharp & Dohme LLCHeart Failure, Renal Impairment

Start: 2014-05-23End: 2014-12-17Updated: 2018-09-21

Open Label Study for the Functional Characterization of Drug Metabolism and Transport

CompletedNCT01788254

Matthias SchwabGenotype-related Drug Metabolism

Start: 2012-01-31End: 2015-05-31Updated: 2015-05-27

Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics

CompletedNCT01845194

Institut fuer anwendungsorientierte Forschung und klinische Studien GmbHDrug Biotransformation, Membrane Transport

Start: 2009-12-31End: 2013-10-31Updated: 2014-04-21

Phase 2

ToRsemide for pOstpartum HYpertension

CompletedNCT02813551

The University of Texas Health Science Center, HoustonPreeclampsia

Start: 2016-08-31End: 2017-09-09Updated: 2019-04-10

Phase 3

TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

CompletedNCT03296813

Duke UniversityHeart Failure

Start: 2018-07-11End: 2022-07-29Updated: 2025-10-16

Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure

CompletedNCT05093621

Yale UniversityHeart Failure

Start: 2021-02-08End: 2023-06-30Updated: 2024-10-15

Phase 4

Weight-Based Torsemide Dosing in Subjects With Heart Failure

CompletedNCT03187509

New York City Health and Hospitals CorporationHeart Failure

Start: 2018-04-17End: 2022-03-14Updated: 2022-03-15

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

RecruitingNCT06218199

Heart Center Research, LLCHeart Failure, Congestive

Start: 2021-07-08End: 2026-12-31Target: 80Updated: 2024-01-29

A Crossover Study of Patients with HF to Compare Natriuretic Effects of IR Torsemide Vs. ER Torsemide Over 12 Hrs

TerminatedNCT06708611

Sarfez Pharmaceuticals, Inc.Heart Failure

Start: 2025-01-15End: 2025-03-25Updated: 2025-03-30

Unknown Phase

Bioequivalency Study of Torsemide Tablets Under Fed Conditions

CompletedNCT00602615

Roxane LaboratoriesEdema

Start: 2003-09-30End: 2003-09-30Updated: 2018-01-23

Bioequivalency Study of Torsemide Tablets Under Fasting Conditions

CompletedNCT00602303

Roxane LaboratoriesEdema

Start: 2003-09-30End: 2003-09-30Updated: 2018-01-23

Journal of the American Society of Nephrology2024-08-2813 citations

On-Treatment Analysis of Torsemide Versus Furosemide for Patients Hospitalized for Heart Failure: A Post-Hoc Analysis of TRANSFORM-HF

European Journal of Heart Failure2024-05-153 citations

Torsemide Versus Furosemide After Discharge in Patients Hospitalized With Heart Failure Across the Spectrum of Ejection Fraction: Findings From TRANSFORM-HF

Circulation Heart Failure2024-03-017 citations

Effect of Torsemide Versus Furosemide on Symptoms and Quality of Life Among Patients Hospitalized for Heart Failure: The TRANSFORM-HF Randomized Clinical Trial

Circulation2023-05-2217 citations

Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure

JAMA2023-01-17164 citations

Torsemide comparison with furosemide for management of heart failure (TRANSFORM-HF) trial

European Heart Journal Acute Cardiovascular Care2022-11-0810 citations

Pragmatic Design of Randomized Clinical Trials for Heart Failure: Rationale and Design of the TRANSFORM-HF Trial.

2021-03-1032 citations

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

Frontiers in Genetics2020-08-2122 citations

Comparative effectiveness of torasemide versus furosemide in symptomatic therapy in heart failure patients: Preliminary results from the randomized TORNADO trial.

2019-01-0115 citations

Torsemide for Prevention of Persistent Postpartum Hypertension in Women With Preeclampsia

Obstetrics and Gynecology2018-10-1026 citations

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.

2016-11-089 citations