Tobramycin inhalation solution

DRUG5 trials

Sponsors

Gilead Sciences, Novartis Pharmaceuticals, Medical Center Alkmaar, Respirion Pharmaceuticals Pty Ltd, Qianfoshan Hospital

Conditions

BronchiectasisCystic FibrosisCystic Fibrosis LungLung InfectionNon-CF BronchiectasisPseudomonas AeruginosaRespiratory Infections, Recurrent, Chronic

Phase 1

A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

CompletedNCT06016088

Respirion Pharmaceuticals Pty LtdCystic Fibrosis Lung, Pseudomonas Aeruginosa, Respiratory Infections, Recurrent, Chronic

Start: 2024-04-01End: 2026-06-22Updated: 2026-06-25

Phase 2

Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis

CompletedNCT02657473

Medical Center AlkmaarNon-CF Bronchiectasis

Start: 2016-08-13End: 2019-12-13Updated: 2019-12-17

Phase 3

Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF

CompletedNCT01641822

Gilead SciencesCystic Fibrosis

Start: 2012-12-31End: 2015-01-31Updated: 2016-05-09

Phase 4

Ease of Use and Microbial Contamination of Tobramycin Inhalation Powder (TIP) Versus Nebulised Tobramycin Inhalation Solution (TIS) and Nebulised Colistimethate (COLI)

CompletedNCT01844778

Novartis PharmaceuticalsCystic Fibrosis

Start: 2013-08-31End: 2015-10-31Updated: 2016-07-27

Unknown Phase

A Study of the Clinical Benefit of Tobramycin Inhalation Solution

Active, not recruitingNCT06106789

Qianfoshan HospitalBronchiectasis, Cystic Fibrosis, Lung Infection

Start: 2023-04-01End: 2024-10-30Target: 1600Updated: 2024-10-17

Related Papers

Treatment with inhaled antibiotics in bronchiectasis, side effects, and evaluation of the tolerance test; analysis from the BATTLE randomized controlled trial

The Clinical Respiratory Journal2023-07-179 citations

The BATTLE study: Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis. Study protocol of a double blind, randomized, placebo-controlled trial: study protocol.

2022-12-063 citations

Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis

Respiratory Research2022-12-0315 citations

Continuous alternating inhaled antibiotics for chronic pseudomonal infection in cystic fibrosis.

2016-05-2436 citations