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Tezspire 210 mg solution for injection in pre-filled syringe

DRUG10 trials

Sponsors

AstraZeneca AB, Philipps-Universitaet Marburg, Centre Hospitalier Universitaire De Montpellier, Imperial College London Limited, Medical University Of Vienna

Conditions

Chronic Obstructive Pulmonary Disease (COPD)Chronic Rhinosinusitis with Nasal PolyposisChronic Rhinosinusitis with Nasal PolypsChronic obstructive pulmonary disease (COPD)Eosinophilic esophagitis (EoE) is a rareEosinophilic granulomatosis with polyangiitis (EGPA)Oral Corticosteroid Dependent AsthmaProgressive pulmonary fibrosis interstitial lung disease with evidence of eosinophilia

Phase 2

Phase 3

A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled 28-week Phase III Efficacy and Safety Study of Tezepelumab in Reducing Oral Corticosteroid Use in Adults with Oral Corticosteroid Dependent Asthma (SUNRISE)
CompletedCTIS2023-504648-33-00
AstraZeneca ABOral Corticosteroid Dependent Asthma
Start: 2022-07-19End: 2025-03-12Target: 76Updated: 2024-11-15
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Efficacy and Safety Study of Tezepelumab in Patients with Eosinophilic Esophagitis (CROSSING)
Active, not recruitingCTIS2023-504277-20-00
AstraZeneca ABchronic inflammatory disorder triggered by an immune response to foods and aeroantigens and characterized by a combination of esophageal dysfunction and eosinophilic infiltration of the esophagus, Eosinophilic esophagitis (EoE) is a rare
Start: 2023-01-30Target: 211Updated: 2026-01-22
REVERT : REVErsing airway Remodelling with Tezepelumab : a protocol for a double blind randomized controlled trial for patients with asthma
RecruitingCTIS2024-513195-18-00
Centre Hospitalier Universitaire De MontpellierSevere asthma
Start: 2023-03-27Target: 150Updated: 2025-02-20
A Multicentre, Randomised, Open-Label, Parallel-Group, Phase IIIb Study to Assess the Potential for Tezepelumab-treated Patients with Severe Asthma to Reduce Background Therapy While Sustaining Asthma Control and Clinical Remission (ARRIVAL)
RecruitingCTIS2024-512113-41-00
AstraZeneca ABSevere Asthma
Start: 2024-11-20Target: 152Updated: 2025-09-24
A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment with Tezepelumab (ESSENCE)
RecruitingCTIS2024-513862-20-00
AstraZeneca ABChronic Rhinosinusitis with Nasal Polyposis
Start: 2025-03-26Target: 356Updated: 2025-12-23
A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (JOURNEY)
RecruitingCTIS2024-517457-27-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2025-06-04Target: 293Updated: 2026-01-14
A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (EMBARK)
RecruitingCTIS2024-517458-90-00
AstraZeneca ABChronic obstructive pulmonary disease (COPD)
Start: 2025-06-06Target: 187Updated: 2025-12-04

Phase 4