Tezspire 210 mg solution for injection in pre-filled syringe
Sponsors
AstraZeneca AB, Philipps-Universitaet Marburg, Centre Hospitalier Universitaire De Montpellier, Imperial College London Limited, Medical University Of Vienna
Conditions
Chronic Obstructive Pulmonary Disease (COPD)Chronic Rhinosinusitis with Nasal PolyposisChronic Rhinosinusitis with Nasal PolypsChronic obstructive pulmonary disease (COPD)Eosinophilic esophagitis (EoE) is a rareEosinophilic granulomatosis with polyangiitis (EGPA)Oral Corticosteroid Dependent AsthmaProgressive pulmonary fibrosis interstitial lung disease with evidence of eosinophilia
Phase 2
Tezepelumab (Anti-TSLP-mab) in progressive pulmonary fibrosis interstitial lung disease with evidence of eosinophilia - A prospective two-armed, phase II clinical multicentre randomized, placebo-controlled (2:1), blinded with open-label extension trial (TEFIBEOS)
RecruitingCTIS2024-510884-51-00
Start: 2025-06-09Target: 39Updated: 2025-11-12
A RAndomised Placebo Controlled Trial - to Explore the Efficacy and Mechanism of Action of Tezepelumab in EGPA- RACE-MATE
WithdrawnCTIS2024-514794-22-01
Target: 10Updated: 2025-05-02
Phase 3
A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled 28-week Phase III Efficacy and Safety Study of Tezepelumab in Reducing Oral Corticosteroid Use in Adults with Oral Corticosteroid Dependent Asthma (SUNRISE)
CompletedCTIS2023-504648-33-00
Start: 2022-07-19End: 2025-03-12Target: 76Updated: 2024-11-15
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Efficacy and Safety Study of Tezepelumab in Patients with Eosinophilic Esophagitis (CROSSING)
Active, not recruitingCTIS2023-504277-20-00
Start: 2023-01-30Target: 211Updated: 2026-01-22
REVERT : REVErsing airway Remodelling with Tezepelumab : a protocol for a double blind randomized controlled trial for patients with asthma
RecruitingCTIS2024-513195-18-00
Start: 2023-03-27Target: 150Updated: 2025-02-20
A Multicentre, Randomised, Open-Label, Parallel-Group, Phase IIIb Study to Assess the Potential for Tezepelumab-treated Patients with Severe Asthma to Reduce Background Therapy While Sustaining Asthma Control and Clinical Remission (ARRIVAL)
RecruitingCTIS2024-512113-41-00
Start: 2024-11-20Target: 152Updated: 2025-09-24
A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment with Tezepelumab (ESSENCE)
RecruitingCTIS2024-513862-20-00
Start: 2025-03-26Target: 356Updated: 2025-12-23
A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (JOURNEY)
RecruitingCTIS2024-517457-27-00
Start: 2025-06-04Target: 293Updated: 2026-01-14
A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (EMBARK)
RecruitingCTIS2024-517458-90-00
Start: 2025-06-06Target: 187Updated: 2025-12-04