Tenofovir disoproxil fumarate (TDF)

DRUG11 trials

Conditions

Acute on Chronic Liver FailureChronic HBV InfectionChronic Hepatitis BHIV InfectionsHIV-1 InfectionsHealthyHepatitis BHepatitis B Virus (HBV)

Early Phase 1

A Study in Chronic Hepatitis B e-Antigen Negative Participants After Discontinuation of Nucleos(t)Ide Analog (NA) Treatment

WithdrawnNCT05550519

Janssen Pharmaceutica N.V., BelgiumHepatitis B, Chronic

Start: 2022-10-31End: 2025-08-28Updated: 2025-06-25

Phase 1

Evaluation of the Cellular Pharmacology of Tenofovir and Emtricitabine According to HIV Infection Status

CompletedNCT01040091

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2009-12-31End: 2014-04-30Updated: 2016-12-16

A Single and Multiple Ascending Dose Study of JNJ-64457744

TerminatedNCT05423106

Janssen Research & Development, LLCHealthy, Hepatitis B, Chronic

Start: 2022-07-04End: 2023-03-20Updated: 2025-02-03

Phase 2

A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection

CompletedNCT04129554

Janssen Sciences Ireland UCHepatitis B, Chronic

Start: 2019-11-06End: 2022-06-09Updated: 2025-02-04

Phase 3

Tenofovir Disoproxil Fumarate/Emtricitabine/Efavirenz Versus Combivir/Efavirenz in Antiretroviral-Naive HIV-1 Infected Subjects

CompletedNCT00112047

Gilead SciencesHIV Infections

Start: 2003-07-31End: 2009-06-30Updated: 2010-10-13

Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples

CompletedNCT00557245

University of WashingtonHIV-1 Infections, HIV Infections

Start: 2008-05-31End: 2013-10-31Updated: 2019-04-19

Evaluation of Tenofovir Disoproxil Fumarate in Adolescents With Chronic Hepatitis B Infection

CompletedNCT00734162

Gilead SciencesHepatitis B Virus (HBV)

Start: 2008-12-31End: 2015-12-31Updated: 2016-09-01

Phase 4

Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure

CompletedNCT01074645

Govind Ballabh Pant HospitalAcute on Chronic Liver Failure, Hepatitis B

Start: 2007-11-30End: 2009-10-31Updated: 2010-02-24

Unknown Phase

Study of Effects of Tenofovir on Bone Health and Kidneys During Pregnancy and Breastfeeding

CompletedNCT01066858

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2011-03-22End: 2015-11-30Updated: 2022-09-23

Long Term Follow-up Registry of Individuals Treated in A Gilead-Sponsored Trial in Individuals With Chronic Hepatitis B Infection

TerminatedNCT02258581

Gilead SciencesChronic Hepatitis B

Start: 2014-12-09End: 2017-08-14Updated: 2017-10-03

Effect of Tenofovir (TDF) on Renal Function in Patients With Chronic Hepatitis B

Not yet recruitingNCT06896630

Assiut UniversityChronic HBV Infection, Renal Function Disorder, Tenofovir Disoproxil Fumarate

Start: 2025-04-10End: 2026-05-01Target: 172Updated: 2025-04-04

2025-02-261 citations

JNJ-73763989 and bersacapavir treatment in nucleos(t)ide analogue-suppressed patients with chronic hepatitis B: REEF-2

Journal of Hepatology2024-04-0534 citations

Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial.

2022-07-205 citations

Impact of postpartum tenofovir-based antiretroviral therapy on bone mineral density in breastfeeding women with HIV enrolled in a randomized clinical trial

PLoS ONE2021-02-0513 citations

Quadrivalent HPV vaccine in HIV-1-infected early adolescent girls and boys in Kenya: Month 7 and 12 post vaccine immunogenicity and correlation with immune status.

2018-10-0518 citations

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

PLoS Pathogens2017-11-0620 citations

Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing

Antimicrobial Agents and Chemotherapy2016-08-3073 citations

Analysis of the Endogenous Deoxynucleoside Triphosphate Pool in HIV-Positive and -Negative Individuals Receiving Tenofovir-Emtricitabine

Antimicrobial Agents and Chemotherapy2016-06-2912 citations

Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women.

2016-03-2934 citations

Reduced Immune Activation During Tenofovir–Emtricitabine Therapy in HIV-Negative Individuals

JAIDS Journal of Acquired Immune Deficiency Syndromes2015-01-2426 citations

Changes in Glomerular Kidney Function Among HIV-1<b>–</b>Uninfected Men and Women Receiving Emtricitabine<b>–</b>Tenofovir Disoproxil Fumarate Preexposure Prophylaxis

JAMA Internal Medicine2014-12-2294 citations

Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.

2014-10-0796 citations

Pregnancy Incidence and Outcomes Among Women Receiving Preexposure Prophylaxis for HIV Prevention

JAMA2014-07-19124 citations

Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.

2014-07-0150 citations

Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

2012-07-112548 citations

Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention.

2011-10-0573 citations