Sham procedure control

DRUG5 trials

Sponsors

Lyra Therapeutics, Ottawa Hospital Research Institute, Bionic Sight LLC, Pulnovo Medical, Inc.

Conditions

Bronchopulmonary Dysplasia (BPD)Cardiovascular DiseasesChronic Rhinosinusitis (Diagnosis)Chronic SinusitisELGAN (22-28SA)Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)Heart FailureHeart Failure With Mid Range Ejection Fraction

Phase 1

A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMD

RecruitingNCT07158775

Bionic Sight LLCGeographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)

Start: 2026-01-08End: 2031-12-01Target: 40Updated: 2026-01-23

Phase 2

Mesenchymal Stromal Cell Therapy to Prevent Bronchopulmonary Dysplasia in Extreme Preterm Infants

Not yet recruitingNCT07058025

Ottawa Hospital Research InstituteBronchopulmonary Dysplasia (BPD), ELGAN (22-28SA)

Start: 2025-10-01End: 2038-09-30Target: 168Updated: 2025-07-10

Phase 3

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults

CompletedNCT05219968

Lyra TherapeuticsChronic Rhinosinusitis (Diagnosis), Chronic Sinusitis

Start: 2022-01-27End: 2024-09-16Updated: 2025-05-02

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)

CompletedNCT05295459

Lyra TherapeuticsChronic Rhinosinusitis (Diagnosis), Chronic Sinusitis

Start: 2022-05-13End: 2025-04-02Updated: 2026-02-19

Unknown Phase

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

Not yet recruitingNCT07214376

Pulnovo Medical, Inc.Cardiovascular Diseases, Heart Failure, Heart Failure With Mid Range Ejection Fraction +5

Start: 2026-04-01End: 2031-12-31Target: 750Updated: 2026-03-12

Related Papers

Impact of long‐acting implantable LYR‐210 corticosteroid matrices on quality of life of patients with chronic rhinosinusitis in the LANTERN study

International Forum of Allergy & Rhinology2023-02-082 citations