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DRUG6 trials

Sponsors

Lyra Therapeutics, Ottawa Hospital Research Institute, Bionic Sight LLC, Pulnovo Medical, Inc., Hippocration General Hospital

Conditions

Bronchopulmonary Dysplasia (BPD)Cardiovascular DiseasesChronic Kidney Disease (Stage 3)Chronic Rhinosinusitis (Diagnosis)Chronic SinusitisELGAN (22-28SA)Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)Heart Failure

Phase 1

A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMD
RecruitingNCT07158775
Bionic Sight LLCGeographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)
Start: 2026-01-08End: 2031-12-01Target: 40Updated: 2026-01-23

Phase 2

Mesenchymal Stromal Cell Therapy to Prevent Bronchopulmonary Dysplasia in Extreme Preterm Infants
Not yet recruitingNCT07058025
Ottawa Hospital Research InstituteBronchopulmonary Dysplasia (BPD), ELGAN (22-28SA)
Start: 2025-10-01End: 2038-09-30Target: 168Updated: 2025-07-10

Phase 3

Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
CompletedNCT05219968
Lyra TherapeuticsChronic Rhinosinusitis (Diagnosis), Chronic Sinusitis
Start: 2022-01-27End: 2024-09-16Updated: 2025-05-02
Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)
CompletedNCT05295459
Lyra TherapeuticsChronic Rhinosinusitis (Diagnosis), Chronic Sinusitis
Start: 2022-05-13End: 2025-04-02Updated: 2026-02-19

Unknown Phase

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
RecruitingNCT07214376
Pulnovo Medical, Inc.Cardiovascular Diseases, Heart Failure, Heart Failure With Mid Range Ejection Fraction +5
Start: 2026-07-30End: 2031-12-31Target: 750Updated: 2026-08-18
Renal Denervation in Chronic Kidney Disease - RDN-CKD Study
Active, not recruitingNCT07742787
Hippocration General HospitalChronic Kidney Disease (Stage 3), Renal Denervation, Uncontrolled Hypertension
Start: 2024-07-04End: 2027-03-07Updated: 2026-08-04

Related Papers

Helping Underdeveloped Lungs with Cells (HULC-2): mesenchymal stromal cells in extreme preterm infants at risk of developing bronchopulmonary dysplasia - a study protocol of a phase 2 multicentre double blind randomised controlled trial in Canada.
2026-07-06
Impact of long‐acting implantable LYR‐210 corticosteroid matrices on quality of life of patients with chronic rhinosinusitis in the LANTERN study
International Forum of Allergy & Rhinology2023-02-082 citations