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Secretin

DRUG11 trials

Sponsors

Elizabeth Hecht, University of Nottingham, Johns Hopkins University, Dartmouth-Hitchcock Medical Center, Children's Hospital Medical Center, Cincinnati

Conditions

AdiposityChronic PancreatitisDiabetesDiabetes MellitusGene MutationGermline Mutation CarrierHealthy VolunteersInjury of Body of Pancreas

Phase 1

Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers
CompletedNCT01452217
University of NottinghamChronic Pancreatitis
Start: 2010-09-30End: 2011-10-31Updated: 2011-10-14
Pancreatic Perfusion Using Secretin and MRI
NCT02458118
University of NottinghamChronic Pancreatitis
Start: 2012-06-30End: 2016-06-30Target: 15Updated: 2016-02-18

Phase 2

Secretin Infusion to Prevent Pancreatic Leaks Following Pancreatic Resection
CompletedNCT02160808
Dartmouth-Hitchcock Medical CenterInjury of Body of Pancreas
Start: 2014-05-31End: 2019-09-21Updated: 2020-03-31
Secretin for Acute Pancreatitis
NCT03686618
ChiRhoClin, Inc.Pancreatitis, Acute
Start: 2018-10-01End: 2019-11-01Target: 40Updated: 2019-04-10

Phase 3

The Cancer of the Pancreas Screening-5 CAPS5)Study
RecruitingNCT02000089
Johns Hopkins UniversityGene Mutation, Germline Mutation Carrier, Lynch Syndrome +2
Start: 2014-01-06End: 2029-06-30Target: 9000Updated: 2025-10-09
Aspiration of Duodenopancreatic Juice After Secretin Stimulation vs Endoscopic Aspiration for Molecular Analysis of Intraductal Papillary Mucinous Intraductal Neoplasia.
NCT05914077
Fundacion Clinic per a la Recerca BiomédicaIntraductal Papillary Mucinous Neoplasm of Pancreas
Start: 2023-09-13End: 2025-01-31Target: 140Updated: 2023-09-18

Phase 4

A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers
CompletedNCT01134848
University of NottinghamSphincter of Oddi Dysfunction
Start: 2009-01-31End: 2010-02-28Updated: 2010-06-02
Imaging Biomarkers of Pancreatic Function and Disease
Enrolling by invitationNCT05659147
Children's Hospital Medical Center, CincinnatiDiabetes Mellitus, Pancreatitis
Start: 2023-01-18End: 2027-12-01Target: 195Updated: 2026-03-18

Unknown Phase

Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection
WithdrawnNCT01094626
Elizabeth HechtIntraductal Papillary Mucinous Neoplasm, Pancreatic Cancer
Start: 2010-04-30End: 2013-03-31Updated: 2016-06-10
MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics
CompletedNCT02869893
Children's Hospital Medical Center, CincinnatiHealthy Volunteers
Start: 2016-08-10End: 2017-04-06Updated: 2020-08-07
The Role of Secretin on the Energy Homeostasis
CompletedNCT04613700
Steno Diabetes Center CopenhagenAdiposity, Diabetes, Metabolic Disease +1
Start: 2020-03-01End: 2020-09-29Updated: 2020-11-05

Related Papers

Secretin infusion decreases food intake in healthy men—a randomized, placebo-controlled, double-blind, crossover study
European Journal of Endocrinology2024-11-181 citations
Effect of intraoperative secretin on operative outcomes in pancreatic resection: A randomized controlled trial
Pancreatology2021-02-092 citations
Alterations in the Duodenal Fluid Microbiome of Patients With Pancreatic Cancer.
2020-11-0577 citations
Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer.
2019-10-3050 citations
Pancreatic Cancer-Induced Diabetes
Oncology Times2017-09-291 citations