Rivipansel

DRUG7 trials

Sponsors

GlycoMimetics Incorporated, Biossil Inc.

Conditions

Anemia, Sickle CellHealthyModerate Hepatic ImpairmentNormal Hepatic FunctionPain CrisisRenal ImpairmentSickle Cell AnemiaSickle Cell Disease

Phase 1

A Study to Evaluate the Effect of IV Doses of GMI-1070 on Qtc Intervals in Healthy African-American Adult Subjects

CompletedNCT01941511

GlycoMimetics IncorporatedHealthy

Start: 2013-08-31End: 2014-08-31Updated: 2020-06-18

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Rivipansel With rHuPH20 in Healthy Subjects

CompletedNCT02217917

GlycoMimetics IncorporatedHealthy

Start: 2015-10-31End: 2016-04-30Updated: 2020-06-18

A Study to Evaluate the Effect of IV Doses of Rivipansel on Subjects With Renal Impairment and in Healthy Subjects

CompletedNCT02813798

GlycoMimetics IncorporatedHealthy, Renal Impairment

Start: 2016-06-30End: 2018-02-28Updated: 2020-06-18

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

CompletedNCT02871570

GlycoMimetics IncorporatedModerate Hepatic Impairment, Normal Hepatic Function

Start: 2016-09-30End: 2017-03-31Updated: 2020-07-09

A Study to Evaluate the Effect of Age on the Pharmacokinetics, Safety and Tolerability of IV Rivipansel.

CompletedNCT02998099

GlycoMimetics IncorporatedHealthy

Start: 2017-01-31End: 2017-03-31Updated: 2020-06-18

Phase 3

Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease

CompletedNCT02187003

Biossil Inc.Anemia, Sickle Cell

Start: 2015-06-17End: 2019-06-27Updated: 2025-03-11

Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease

TerminatedNCT02433158

GlycoMimetics IncorporatedPain Crisis, Sickle Cell Anemia, Sickle Cell Disease +2

Start: 2015-12-16End: 2019-11-15Updated: 2021-02-10

Related Papers

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Blood2022-08-1837 citations

Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis

Blood2020-11-0512 citations

Effect of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intravenous Rivipansel

Clinical Pharmacology in Drug Development2020-06-243 citations