Resiniferatoxin

DRUG9 trials

Sponsors

National Institute of Neurological Disorders and Stroke (NINDS), Sorrento Therapeutics, Inc., National Institutes of Health Clinical Center (CC)

Conditions

Intractable Cancer PainIntractable PainKnee OsteoarthritisKnee Pain ChronicMorton's NeuromaOsteo Arthritis KneeOsteoarthritis, KneePain

Phase 1

Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain

Not yet recruitingNCT02522611

National Institute of Neurological Disorders and Stroke (NINDS)Intractable Pain, Palliative Care

Start: 2026-08-27End: 2026-12-01Target: 30Updated: 2026-09-02

Study to Evaluate Safety and MTD of Epidural Resiniferatoxin Injection for Treatment of Intractable Cancer Pain

CompletedNCT03226574

Sorrento Therapeutics, Inc.Intractable Cancer Pain

Start: 2017-09-01End: 2020-06-18Updated: 2020-10-20

Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis

CompletedNCT03542838

Sorrento Therapeutics, Inc.Osteoarthritis, Knee, Pain, Knee

Start: 2018-07-12End: 2021-02-11Updated: 2021-04-01

Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain

CompletedNCT05695339

National Institutes of Health Clinical Center (CC)Morton's Neuroma

Start: 2025-03-13End: 2025-10-15Updated: 2026-04-13

Phase 2

Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis

Sorrento Therapeutics, Inc.Knee Osteoarthritis, Knee Pain Chronic, Osteoarthritis, Knee

Start: 2021-11-15End: 2023-11-30Updated: 2023-01-17

Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced Cancer

SuspendedNCT05067257

Sorrento Therapeutics, Inc.Pain, Pain Cancer, Pain, Intractable

Start: 2025-09-30End: 2027-12-31Target: 120Updated: 2024-03-18

Phase 3

A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee

WithdrawnNCT04044742

Sorrento Therapeutics, Inc.Knee Pain Chronic, Osteoarthritis, Knee

Start: 2020-12-31End: 2023-03-31Updated: 2021-11-09

Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed

WithdrawnNCT04386980

Sorrento Therapeutics, Inc.Knee Pain Chronic, Osteoarthritis, Knee, Osteo Arthritis Knee

Start: 2021-04-30End: 2022-06-30Updated: 2021-11-09

Phase 3 Study to Assess Resiniferatoxin vs Standard of Care for the Treatment of Intractable Cancer Pain

WithdrawnNCT04572776

Sorrento Therapeutics, Inc.Pain Cancer, Pain, Intractable

Start: 2020-12-31End: 2023-03-31Updated: 2021-11-09