Rasburicase

DRUG19 trials

Sponsors

Lysarc, F. Hoffmann-La Roche AG, Fondazione Gimema Franco Mandelli Onlus, Heinrich-Heine-Universitaet Duesseldorf, Children's Oncology Group

Conditions

Adult Acute Lymphocytic LeukemiaAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)B-cell non-Hodgkin lymphoma (NHL)

Phase 1

Pharmacokinetic Evaluation of Rasburicase in Patients With Leukemia and/or Lymphoma at High Risk of TLS

CompletedNCT00360438

M.D. Anderson Cancer CenterLeukemia, Lymphoma, Tumor Lysis Syndrome

Start: 2006-07-31End: 2007-04-30Updated: 2012-08-01

Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant

CompletedNCT00513474

Massachusetts General HospitalChronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia +4

Start: 2008-01-31End: 2013-02-12Updated: 2017-05-25

An Open-Label, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination with Polatuzumab Vedotin in Patients with B-Cell Non-Hodgkin Lymphoma

Active, not recruitingCTIS2023-506986-74-00

F. Hoffmann-La Roche AGB-cell non-Hodgkin lymphoma (NHL)

Start: 2021-12-27Target: 17Updated: 2025-08-04

Phase-I/II trial to assess the safety and efficacy of Venetoclax in addition to sequential conditioning with Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for allogeneic blood stem cell transplantation in patients with MDS, CMML or sAML

RecruitingCTIS2024-514688-24-00

Heinrich-Heine-Universitaet Duesseldorfchronic myelomonocytic leukemia (CMML) or secondary acute myeloid leukemia (sAML) before stem cell transplantation, Patients with myelodysplastic syndrome (MDS)

Start: 2023-05-26Target: 38Updated: 2025-10-09

Phase 2

Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

CompletedNCT00057811

Children's Oncology GroupChildhood Burkitt Lymphoma, Childhood Diffuse Large Cell Lymphoma, Childhood Immunoblastic Large Cell Lymphoma +9

Start: 2004-06-30End: 2014-07-31Updated: 2014-09-19

Lowering Serum Uric Acid to Prevent Acute Kidney Injury

CompletedNCT00756964

University of FloridaHyperuricemia

Start: 2008-10-31End: 2011-08-31Updated: 2012-09-03

Rasburicase in Patients at High Risk for Tumor Lysis Syndrome (TLS) During Cycle-2

CompletedNCT01200485

M.D. Anderson Cancer CenterLeukemia, Lymphoma

Start: 2011-04-30End: 2016-07-31Updated: 2020-01-31

Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies

TerminatedNCT01564277

Roswell Park Cancer InstituteAdult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) +16

Start: 2011-09-29End: 2016-05-28Updated: 2018-01-09

Daratumumab in adults with Very High-Risk T-Lineage Acute Lymphoblastic Leukemia (ALL) Treated According to the ALL National Treatment Program (DARATALL-VHR)- GIMEMA ALL3024

RecruitingCTIS2024-511627-34-00

Fondazione Gimema Franco Mandelli OnlusVery High-Risk T-Lineage Acute Lymphoblastic Leukemia (ALL)

Start: 2024-10-17Target: 31Updated: 2025-12-23

Phase 3

Treatment of Hyperuricemia With Rasburicase in Patients With Acute Lymphoblastic Leukemia or High Grade Lymphoma

CompletedNCT00199043

Goethe UniversityAdult Acute Lymphocytic Leukemia, High-grade Lymphoma

Start: 2003-05-31End: 2008-05-31Updated: 2023-03-17

Rasburicase (Fasturtec) Registration Trial

TerminatedNCT00607152

SanofiHyperuricemia

Start: 2007-10-31End: 2009-01-31Updated: 2014-05-08

MorningLyte: A Phase III randomized, open-label, international, multicenter study evaluating the efficacy and safety of mosunetuzumab plus lenalidomide in comparison to anti-CD20 monoclonal antibody plus chemotherapy in subjects with previously untreated FLIPI 2-5 follicular lymphoma

RecruitingCTIS2023-505436-35-00

LysarcUntreated FLIPI 2-5 Follicular Lymphoma

Start: 2024-06-03Target: 674Updated: 2025-10-23

Phase 4

Rasburicase in Tumor Lysis Syndrome

CompletedNCT00302653

SanofiHyperuricemia

Start: 2006-02-28Updated: 2009-09-25

Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome

CompletedNCT00563771

SanofiHyperuricemia

Start: 2003-03-31End: 2004-01-31Updated: 2008-01-28

Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome

Active, not recruitingNCT04745910

M.D. Anderson Cancer CenterHematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Tumor Lysis Syndrome

Start: 2022-04-05End: 2026-07-31Updated: 2025-12-18

Rasburicase Treatment in Chronic Gouty Arthritis

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityChronic Gout

Start: 2022-06-15End: 2025-04-15Target: 60Updated: 2023-05-09

Unknown Phase

Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients

CompletedNCT00186940

St. Jude Children's Research HospitalHyperuricemia, Leukemia, Lymphoma +1

Start: 2005-03-31End: 2010-02-28Updated: 2017-04-25

Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status

CompletedNCT01931527

Washington University School of MedicineHyperuricemia, Metabolic Syndrome, Obesity

Start: 2006-07-31End: 2012-11-30Updated: 2018-08-14

Uric Acid Effects on Endothelium and Oxydative Stress

CompletedNCT03395977

Erasme University HospitalCardiovascular System, Endothelial Function, Hypertension +1

Start: 2018-01-03End: 2020-02-27Updated: 2020-02-28

Related Papers

Digital Twins As Control Groups to Accelerate Assessment of Safety and Efficacy of Novel Treatment Strategies in Ph-Negative Acute Lymphoblastic Leukemia

Blood2024-11-05

Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study

Physiological Reports2021-08-2610 citations

Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.

2019-11-2230 citations

EFFECTS OF URIC ACID ON ENDOTHELIAL FUNCTION, OXIDATIVE STRESS, BLOOD PRESSURE AND THE RENIN ANGIOTENSIN SYSTEM

Journal of Hypertension2019-06-22

Efficacy and Safety of Two Comparable Single Low Doses of Rasburicase Followed By Allopurinol in Adult Patients with Acute Leukemia

Blood2017-12-07